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EOSINOPHILIC MENINGITIS CAUSED BY ANGIOSTRONGYLUS CANTONENSIS ASSOCIATED WITH EATING RAW SNAILS: CORRELATION OF BRAIN MAGNETICRESONANCE IMAGING SCANS WITH CLINICAL FINDINGS

Angiostrongylus cantonensis is the most common cause of eosinophilic meningitis worldwide. Human infection occurs after ingestion of the worms in raw snails or fish that serve as intermediate hosts. Two outbreaks of central nervous system infection with A. cantonensis occurred in Kaoshiung, Taiwan, during 1998 and 1999 among Thai laborers who ate raw snails. A detailed clinical studies of 17 of these patients was conducted, including study of 13 patients who underwent magnetic resonance imaging (MRI) scans of the brain. The MRI scans revealed high signal intensities over the globus pallidus and cerebral peduncle on TI-weighted imaging, leptomeningeal enhancement, ventriculomegaly, and punctate areas of abnormal enhancement within the cerebral and cerebellar hemisphere on gadolinium-enhancing T1 imaging, and a hyperintense signal on T2-weighted images. There was a significant correlation between severity of headache, cerebrospinal fluid (CSF) pleocytosis, and CSF and blood eosinophilia with MRI signal intensity in T1-weighted imaging (P < 0.05). Eosinophilic meningitis produced by A. cantonensis needs to added to the list of causes of hyperintense basal ganglia lesions found on T1-weighted MRI scans in tropical countries.

Received June 19, 2001. Accepted for publication November 18, 2002.

Authors’ addresses: Hung-Chin Tsai, Yung-Ching Liu, Susan Shin-Jung Lee, Yao-Shen Chen, Shue-Ren Wann, Wei-Ru Lin, Chun-Kai Huang, Hsi-Hsun Lin, and Muh-Yong Yen, Section of Infectious Diseases, Department of Medicine, Kaohsiung Veterans General Hospital, 386 Ta-Chung 1st Road, Kaohsiung, Taiwan, National Yang-Ming University, Taipei, Taiwan, Republic of China, Calvin M. Kunin, Department of Internal Medicine, Ohio State University, Room M110 Starling Loving Hall, 320 W 10^th Avenue, Columbus, OH 43210. Ping H. Lai, Department of Radiology, Kaohsiung Veterans General Hospital, Kaohsiung, Taiwan. Luo-Ping Ger, Department of Medical Research, Kaohsiung General Veterans Hospital, Kaohsiung, Taiwan. Hung-Chin Tsai, Graduate Institute of Medicine, Kaohsiung Medical University, Kaohsiung, Taiwan.

Reprint requests: Yung-Ching Liu, Section of Infectious Diseases and Department of Medicine, Kaohsiung Veterans General Hospital, 386 Ta-Chung 1st Road, Kaohsiung, Taiwan, Telephone: 886-7-3468096, Fax: 886-7-3468292, E-mail: ycliu{at}isca.vghks.gov.tw

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