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Am. J. Trop. Med. Hyg., 67(5), 2002, pp. 459-464
Copyright © 2002 by The American Society of Tropical Medicine and Hygiene

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American Journal of Tropical Medicine and Hygiene, Vol 67, Issue 5, 459-464
Copyright © 2002 by American Society of Tropical Medicine and Hygiene

Research Articles


The population structure of Plasmodium falciparum and Plasmodium vivax during an epidemic of malaria in the Eastern Highlands of Papua New Guinea

I Mueller, J Kaiok, JC Reeder, and A Cortes

Although most of the Papua New Guinea highlands are too high for stable malaria transmission, local epidemics are a regular feature of the region. Few detailed descriptions of such epidemics are available, however. We describe the investigation of a malaria epidemic in the Obura Valley, Eastern Highlands Province, Papua New Guinea. Of the 244 samples examined by microscopy, 6.6% were positive for Plasmodium falciparum only, 9.4% were positive for Plasmodium vivax only, and 1.2% were mixed infections. MSP2 and MSP3alpha genotyping and AMA1 sequencing were used to determine the genetic variation present in a sample of P. falciparum and P. vivax infections. The P. vivax infections were found to be genetically highly diverse. In contrast, all P. falciparum samples were of a single genotype. This striking difference in genetic diversity suggests endemic, low-level local transmission for P. vivax but an outside introduction of P. falciparum as the most likely source of the epidemic.


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 Am J Trop Med HygHome page
I. MUELLER, P. NAMUIGI, J. KUNDI, R. IVIVI, T. TANDRAPAH, S. BJORGE, and J. C. REEDER
EPIDEMIC MALARIA IN THE HIGHLANDS OF PAPUA NEW GUINEA
Am J Trop Med Hyg, May 1, 2005; 72(5): 554 - 560.
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 Antimicrob. Agents Chemother.Home page
M. D. Hastings, J. D. Maguire, M. J. Bangs, P. A. Zimmerman, J. C. Reeder, J. K. Baird, and C. H. Sibley
Novel Plasmodium vivax dhfr Alleles from the Indonesian Archipelago and Papua New Guinea: Association with Pyrimethamine Resistance Determined by a Saccharomyces cerevisiae Expression System
Antimicrob. Agents Chemother., February 1, 2005; 49(2): 733 - 740.
[Abstract] [Full Text] [PDF]

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 Infect. Immun.Home page
A. Cortes, M. Mellombo, I. Mueller, A. Benet, J. C. Reeder, and R. F. Anders
Geographical Structure of Diversity and Differences between Symptomatic and Asymptomatic Infections for Plasmodium falciparum Vaccine Candidate AMA1
Infect. Immun., March 1, 2003; 71(3): 1416 - 1426.
[Abstract] [Full Text] [PDF]


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Copyright © 2002 by the American Society of Tropical Medicine and Hygiene.