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Am. J. Trop. Med. Hyg., 67(4), 2002, pp. 430-435
Copyright © 2002 by The American Society of Tropical Medicine and Hygiene

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American Journal of Tropical Medicine and Hygiene, Vol 67, Issue 4, 430-435
Copyright © 2002 by American Society of Tropical Medicine and Hygiene

Research Articles


The effect of antibacterial soap on impetigo incidence, Karachi, Pakistan

S Luby, M Agboatwalla, BM Schnell, RM Hoekstra, MH Rahbar, and BH Keswick

We conducted a study to determine if soap containing 1.2% triclocarban would be effective in reducing the incidence of impetigo. We randomized 162 households in a low-income neighborhood of Karachi, Pakistan, to receive a regular supply of 1.2% triclocarban-containing soap (n = 81) or an identically appearing placebo (n = 81); 79 households in a nearby neighborhood were enrolled as standard practice controls. After adjustment for household clustering and covariates, the incidence of impetigo among children living in households receiving triclocarban-containing soap (1.10 episodes per 100 person-weeks) was 23% lower than in households receiving placebo soap (P = 0.28) and 43% lower than the standard habit and practice controls (P = 0.02). The routine use of triclocarban-containing soap by children living in a community with a high incidence of impetigo was associated with a reduced incidence of impetigo.


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