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Am. J. Trop. Med. Hyg., 67(2), 2002, pp. 196-200
Copyright © 2002 by The American Society of Tropical Medicine and Hygiene

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American Journal of Tropical Medicine and Hygiene, Vol 67, Issue 2, 196-200
Copyright © 2002 by American Society of Tropical Medicine and Hygiene

Research Articles


The impact of single-dose diethylcarbamazine treatment of bancroftian filariasis in a low-endemicity setting in Egypt

RM Ramzy, M el-Setouhy, H Helmy, AM Kandil, ES Ahmed, HA Farid, R Faris, and GJ Weil

This study was designed to evaluate the effect of a single dose of diethylcarbamazine (DEC, 6 mg/kg) on Wuchereria bancrofti infections in a low-endemicity setting in Egypt (microfilaremia, or MF, 3.7%, median MF 34/mL). Subjects with MF or filarial antigenemia were treated and restudied 1 year later. Treatment with DEC dramatically reduced blood MF counts, with clearance in 69% of subjects. Treatment also reduced filarial antigen levels, but low clearance rates suggest that some adult worms survived treatment in most patients. Mass treatment was administered in one village; 27 months later, MF prevalence had decreased 84% (from 4.9% to 0.8%). These results show that single-dose DEC treatment can have a major effect on MF prevalence rates and levels in low-endemicity settings. Although the World Health Organization advocates repeated multidrug regimens for filariasis elimination, mass treatment with DEC alone may be sufficient to interrupt transmission in areas with low infection intensities and prevalence rates.


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H. A. FARID, R. E. HAMMAD, M. M. HASSAN, R. M. R. RAMZY, M. EL SETOUHY, and G. J. WEIL
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P. E. SIMONSEN, D. W. MEYROWITSCH, D. A. MUKOKO, E. M. PEDERSEN, M. N. MALECELA-LAZARO, R. T. RWEGOSHORA, J. H. OUMA, N. MASESE, W. G. JAOKO, and E. MICHAEL
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H. A. FARID, R. E. HAMMAD, D. A. SOLIMAN, M. A. EL SETOUHY, R. M. R. RAMZY, and G. J. WEIL
RELATIONSHIPS BETWEEN WUCHERERIA BANCROFTI MICROFILARIA COUNTS IN HUMAN BLOOD AND PARASITE UPTAKE AND MATURATION IN CULEX PIPIENS, WITH OBSERVATIONS ON THE EFFECTS OF DIETHYLCARBAMAZINE TREATMENT ON THESE PARAMETERS
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Copyright © 2002 by the American Society of Tropical Medicine and Hygiene.