AJTMH HINARI
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     

Am. J. Trop. Med. Hyg., 67(1), 2002, pp. 76-84
Copyright © 2002 by The American Society of Tropical Medicine and Hygiene

This Article
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Right arrow Citation Map
Services
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow reprints & permissions
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Yazi Mendoza, M
Right arrow Articles by del Angel, R.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Yazi Mendoza, M
Right arrow Articles by del Angel, R.
Related Collections
Right arrow Dengue
American Journal of Tropical Medicine and Hygiene, Vol 67, Issue 1, 76-84
Copyright © 2002 by American Society of Tropical Medicine and Hygiene

Research Articles


A putative receptor for dengue virus in mosquito tissues: localization of a 45-kDa glycoprotein

M Yazi Mendoza, JS Salas-Benito, H Lanz-Mendoza, S Hernandez-Martinez, and RM del Angel

Dengue virus (DENV) infects target cells by attaching to various cell receptors, many of which are still unknown. In C6/36 cells (Aedes albopictus cell line), DENV-4 bound to two glycoproteins of 40 and 45 kDa, located on the cell surface. Preincubation of cells with polyclonal antibody against the 45-kDa protein specifically blocked DENV-4 infection of C6/36 cells. The antibody and purified DENV-4 detected the 45-kDa molecule in total extracts from eggs, larvae, and pupae as well as from the midgut, ovary, and salivary glands from adult-stage Aedes aegypti mosquitoes, whereas in malphigian tubules it was absent. This suggests that the distribution of the 45-kDa protein correlates with tissue tropism of DENV infection in mosquitoes. The 45-kDa molecule was not detected in Anopheles albimanus mosquito. The relevance of our findings is discussed from the pathogenetic and vector competence viewpoints.


This article has been cited by other articles:


Home page
 J. Virol.Home page
G. Anez, R. Men, K. H. Eckels, and C.-J. Lai
Passage of Dengue Virus Type 4 Vaccine Candidates in Fetal Rhesus Lung Cells Selects Heparin-Sensitive Variants That Result in Loss of Infectivity and Immunogenicity in Rhesus Macaques
J. Virol., October 15, 2009; 83(20): 10384 - 10394.
[Abstract] [Full Text] [PDF]

Home page
 Am J Trop Med HygHome page
J. Salas-Benito, J. R.-D. Valle, M. Salas-Benito, I. Ceballos-Olvera, C. Mosso, and R. M. del Angel
Evidence that the 45-kD Glycoprotein, Part of a Putative Dengue Virus Receptor Complex in the Mosquito Cell Line C6/36, Is a Heat-Shock Related Protein
Am J Trop Med Hyg, August 1, 2007; 77(2): 283 - 290.
[Abstract] [Full Text] [PDF]

Home page
 Infect. Immun.Home page
R. R. Dinglasan and M. Jacobs-Lorena
Insight into a Conserved Lifestyle: Protein-Carbohydrate Adhesion Strategies of Vector-Borne Pathogens
Infect. Immun., December 1, 2005; 73(12): 7797 - 7807.
[Full Text] [PDF]

Home page
 J. Virol.Home page
V. Brault, S. Perigon, C. Reinbold, M. Erdinger, D. Scheidecker, E. Herrbach, K. Richards, and V. Ziegler-Graff
The Polerovirus Minor Capsid Protein Determines Vector Specificity and Intestinal Tropism in the Aphid
J. Virol., August 1, 2005; 79(15): 9685 - 9693.
[Abstract] [Full Text] [PDF]

Home page
 J. Virol.Home page
J.-J. Hung, M.-T. Hsieh, M.-J. Young, C.-L. Kao, C.-C. King, and W. Chang
An External Loop Region of Domain III of Dengue Virus Type 2 Envelope Protein Is Involved in Serotype-Specific Binding to Mosquito but Not Mammalian Cells
J. Virol., January 1, 2004; 78(1): 378 - 388.
[Abstract] [Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Copyright © 2002 by the American Society of Tropical Medicine and Hygiene.