AJTMH ASTMH Job Mart
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     

Am. J. Trop. Med. Hyg., 66(4), 2002, pp. 338-345
Copyright © 2002 by The American Society of Tropical Medicine and Hygiene

This Article
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Right arrow Citation Map
Services
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow reprints & permissions
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Ji, J
Right arrow Articles by Soong, L
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Ji, J
Right arrow Articles by Soong, L
Related Collections
Right arrow Leishmaniasis
American Journal of Tropical Medicine and Hygiene, Vol 66, Issue 4, 338-345
Copyright © 2002 by American Society of Tropical Medicine and Hygiene

Research Articles


Analysis of T helper cell responses during infection with Leishmania amazonensis

J Ji, J Sun, H Qi, and L Soong

Most inbred strains of mice are susceptible to Leishmania amazonensis infection and develop progressive cutaneous lesions. However, the role of Th subsets in the disease and the molecular basis of pathogenesis are unclear. To address this issue, we examined the frequency of cytokine-producing CD4+ T cells and the profile of alphabeta T cell receptor (TCR) usage in infected BALB/c mice. At different infection stages, CD4+ cells of draining lymph nodes contained comparable frequencies of Th1 and Th2 cells, produced comparable levels of interleukin-4 (IL-4) and interferon-gamma in vitro, and showed no significant bias in aalphabetaTCR usage. However, T cells became highly polarized to a Th2 phenotype (IL-4+, IL-10+) within a few cycles of in vitro restimulation. These Th2 cells preferentially expressed Valpha2, Vbeta4, or Vbeta8.1/8.2, and significantly exacerbated disease in cell-transferred mice. Thus, unlike a Th2-dominant phenotype seen in L. major infection, a mixed Th1/Th2 response can be maintained in L. amazonensis-infected mice via an as-yet-unidentified mechanism.


This article has been cited by other articles:


Home page
 J. Immunol.Home page
L. Soong
Modulation of Dendritic Cell Function by Leishmania Parasites
J. Immunol., April 1, 2008; 180(7): 4355 - 4360.
[Abstract] [Full Text] [PDF]

Home page
 Infect. Immun.Home page
R. E. Vasquez, L. Xin, and L. Soong
Effects of CXCL10 on Dendritic Cell and CD4+ T-Cell Functions during Leishmania amazonensis Infection
Infect. Immun., January 1, 2008; 76(1): 161 - 169.
[Abstract] [Full Text] [PDF]

Home page
 J. Immunol.Home page
U. Gaur, S. C. Roberts, R. P. Dalvi, I. Corraliza, B. Ullman, and M. E. Wilson
An Effect of Parasite-Encoded Arginase on the Outcome of Murine Cutaneous Leishmaniasis
J. Immunol., December 15, 2007; 179(12): 8446 - 8453.
[Abstract] [Full Text] [PDF]

Home page
 Infect. Immun.Home page
L. Xin, Y. Li, and L. Soong
Role of Interleukin-1{beta} in Activating the CD11chigh CD45RB Dendritic Cell Subset and Priming Leishmania amazonensis- Specific CD4+ T Cells In Vitro and In Vivo
Infect. Immun., October 1, 2007; 75(10): 5018 - 5026.
[Abstract] [Full Text] [PDF]

Home page
 Infect. Immun.Home page
A. E. Ramer, Y. F. Vanloubbeeck, and D. E. Jones
Antigen-Responsive CD4+ T Cells from C3H Mice Chronically Infected with Leishmania amazonensis Are Impaired in the Transition to an Effector Phenotype
Infect. Immun., March 1, 2006; 74(3): 1547 - 1554.
[Abstract] [Full Text] [PDF]

Home page
 J. Immunol.Home page
J. L. M. Wanderley, M. E. C. Moreira, A. Benjamin, A. C. Bonomo, and M. A. Barcinski
Mimicry of Apoptotic Cells by Exposing Phosphatidylserine Participates in the Establishment of Amastigotes of Leishmania (L) amazonensis in Mammalian Hosts
J. Immunol., February 1, 2006; 176(3): 1834 - 1839.
[Abstract] [Full Text] [PDF]

Home page
 J. Immunol.Home page
J. Ji, J. Masterson, J. Sun, and L. Soong
CD4+CD25+ Regulatory T Cells Restrain Pathogenic Responses during Leishmania amazonensis Infection
J. Immunol., June 1, 2005; 174(11): 7147 - 7153.
[Abstract] [Full Text] [PDF]

Home page
 Infect. Immun.Home page
K. Campbell, V. Popov, and L. Soong
Identification and Molecular Characterization of a Gene Encoding a Protective Leishmania amazonensis Trp-Asp (WD) Protein
Infect. Immun., April 1, 2004; 72(4): 2194 - 2202.
[Abstract] [Full Text] [PDF]

Home page
 Infect. Immun.Home page
N. B. Norsworthy, J. Sun, D. Elnaiem, G. Lanzaro, and L. Soong
Sand Fly Saliva Enhances Leishmania amazonensis Infection by Modulating Interleukin-10 Production
Infect. Immun., March 1, 2004; 72(3): 1240 - 1247.
[Abstract] [Full Text] [PDF]

Home page
 Infect. Immun.Home page
K. Campbell, H. Diao, J. Ji, and L. Soong
DNA Immunization with the Gene Encoding P4 Nuclease of Leishmania amazonensis Protects Mice against Cutaneous Leishmaniasis
Infect. Immun., November 1, 2003; 71(11): 6270 - 6278.
[Abstract] [Full Text] [PDF]

Home page
 Infect. Immun.Home page
J. Ji, J. Sun, and L. Soong
Impaired Expression of Inflammatory Cytokines and Chemokines at Early Stages of Infection with Leishmania amazonensis
Infect. Immun., August 1, 2003; 71(8): 4278 - 4288.
[Abstract] [Full Text] [PDF]

Home page
 Infect. Immun.Home page
E. A. F. Coelho, C. A. P. Tavares, F. A. A. Carvalho, K. F. Chaves, K. N. Teixeira, R. C. Rodrigues, H. Charest, G. Matlashewski, R. T. Gazzinelli, and A. P. Fernandes
Immune Responses Induced by the Leishmania (Leishmania) donovani A2 Antigen, but Not by the LACK Antigen, Are Protective against Experimental Leishmania (Leishmania) amazonensis Infection
Infect. Immun., July 1, 2003; 71(7): 3988 - 3994.
[Abstract] [Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Copyright © 2002 by the American Society of Tropical Medicine and Hygiene.