AJTMH Transactions of the Royal Society of Tropical Medicine and Hygiene
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     

Am. J. Trop. Med. Hyg., 66(2), 2002, pp. 143-146
Copyright © 2002 by The American Society of Tropical Medicine and Hygiene

This Article
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow reprints & permissions
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Sundar, S
Right arrow Articles by Buffels, R
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Sundar, S
Right arrow Articles by Buffels, R
Related Collections
Right arrow Leishmaniasis
American Journal of Tropical Medicine and Hygiene, Vol 66, Issue 2, 143-146
Copyright © 2002 by American Society of Tropical Medicine and Hygiene

Research Articles


Low-dose liposomal amphotericin B in refractory Indian visceral leishmaniasis: a multicenter study

S Sundar, TK Jha, CP Thakur, M Mishra, VR Singh, and R Buffels

In this randomized, double-blind, dose-ranging, multicenter trial, 84 patients with visceral leishmaniasis refractory to antimony therapy were administered liposomal amphotericin B (AmBisome) at cumulative doses of 3.75, 7.5, and 15.0 mg/kg for 5 consecutive days. Posttreatment apparent cure and definite cure were assessed at 2 weeks and 6 months after the end of therapy, respectively. Mild to moderate infusion-related fever and rigors were seen in 29 and 44% of patients, respectively. One patient each in the 3.75- and 7.5-mg groups had detectable parasites on splenic smear at posttreatment evaluation. At 6 months' follow-up, however, 2, 1, and 1 patients relapsed in the 3.75-, 7.5-, and 15.0-mg groups, resulting in definite cure rates of 89, 93, and 97%, respectively. There was no significant difference in the cure rates of the 3 groups. Low-dose liposomal amphotericin B given for 5 days can cure most patients with Indian kala-azar.


This article has been cited by other articles:


Home page
 Am J Trop Med HygHome page
T. K. JHA, S. SUNDAR, C. P. THAKUR, J. M. FELTON, A. J. SABIN, and J. HORTON
A PHASE II DOSE-RANGING STUDY OF SITAMAQUINE FOR THE TREATMENT OF VISCERAL LEISHMANIASIS IN INDIA
Am J Trop Med Hyg, December 1, 2005; 73(6): 1005 - 1011.
[Abstract] [Full Text] [PDF]

Home page
 Am J Trop Med HygHome page
H. W. MURRAY
TREATMENT OF VISCERAL LEISHMANIASIS IN 2004
Am J Trop Med Hyg, December 1, 2004; 71(6): 787 - 794.
[Abstract] [Full Text] [PDF]

Home page
 J Antimicrob ChemotherHome page
P. Pagliano, M. Rossi, C. Rescigno, S. Altieri, M. G. Coppola, M. Gramiccia, A. Scalone, L. Gradoni, and F. Faella
Mediterranean visceral leishmaniasis in HIV-negative adults: a retrospective analysis of 64 consecutive cases (1995-2001)
J. Antimicrob. Chemother., August 1, 2003; 52(2): 264 - 268.
[Abstract] [Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Copyright © 2002 by the American Society of Tropical Medicine and Hygiene.