AJTMH ASTMH MEMBERSHIP INFORMATION: astmh@astmh.org
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     

Am. J. Trop. Med. Hyg., 66(2), 2002, pp. 137-139
Copyright © 2002 by The American Society of Tropical Medicine and Hygiene

This Article
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow reprints & permissions
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Diallo, T.
Right arrow Articles by Garraud, O
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Diallo, T.
Right arrow Articles by Garraud, O
Related Collections
Right arrow Malaria
American Journal of Tropical Medicine and Hygiene, Vol 66, Issue 2, 137-139
Copyright © 2002 by American Society of Tropical Medicine and Hygiene

Research Articles


Short report: differential evolution of immunoglobulin G1/G3 antibody responses to Plasmodium falciparum MSP1(19) over time in malaria-immune adult Senegalese patients

TO Diallo, A Spiegel, A Diouf, L Lochouarn, DC Kaslow, A Tall, R Perraut, and O Garraud

This study examined the evolution of immunoglobulin (Ig) G1 and IgG3 antibodies against the asexual stage Plasmodium falciparum protein, MSP1(19), before and after a heavy malaria transmission period in clinically immune Senegalese subjects living under different epidemiological conditions. Plasma was tested for antibodies to a yeast-produced, recombinant PfMSP1(19) antigen (the Q-KNG allelic variant) that has previously been demonstrated to react with IgG1, IgG3, or both in the majority of these people. Anti-P. falciparum antibodies of the IgG1 and IgG3 subclasses, previously reported to be associated with protection, were shown to evolve independently one from another after the transmission period in both settings. These results suggest differential regulation of MSP1(19)-specific IgG1 and IgG3. The precise role of these antibody isotypes in maintaining malaria immunity remains to be determined.


This article has been cited by other articles:


Home page
 J. Immunol.Home page
M. N. Wykes, Y.-H. Zhou, X. Q. Liu, and M. F. Good
Plasmodium yoelii Can Ablate Vaccine-Induced Long-Term Protection in Mice
J. Immunol., August 15, 2005; 175(4): 2510 - 2516.
[Abstract] [Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Copyright © 2002 by the American Society of Tropical Medicine and Hygiene.