AJTMH HINARI
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     

Am. J. Trop. Med. Hyg., 65(5), 2001, pp. 450-455
Copyright © 2001 by The American Society of Tropical Medicine and Hygiene

This Article
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow reprints & permissions
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Wongsrichanalai, C
Right arrow Articles by Kawamoto, F
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Wongsrichanalai, C
Right arrow Articles by Kawamoto, F
Related Collections
Right arrow Travel Medicine
Right arrow Malaria
American Journal of Tropical Medicine and Hygiene, Vol 65, Issue 5, 450-455
Copyright © 2001 by American Society of Tropical Medicine and Hygiene

Research Articles


In vitro susceptibility of Plasmodium falciparum isolates from Myanmar to antimalarial drugs

C Wongsrichanalai, K Lin, LW Pang, MA Faiz, H Noedl, T Wimonwattrawatee, A Laoboonchai, and F Kawamoto

In vitro drug susceptibility profiles were assessed in 75 Plasmodium falciparum isolates from 4 sites in Myanmar. Except at Mawlamyine, the site closest to the Thai border, prevalence and degree of resistance to mefloquine were lower among the Myanmar isolates as compared with those from Thailand. Geometric mean concentration that inhibits 50% (IC50) and 90% (IC90) of Mawlamyine isolates were 51 nM (95% confidence interval [CI], 40-65) and 124 nM (95% CI, 104-149), respectively. At the nearest Thai site, Maesod, known for high-level multidrug resistance, the corresponding values for mefloquine IC50 and IC90 were 92 nM (95% CI, 71-121) and 172 nM (95% CI, 140-211). Mefloquine susceptibility of P. falciparum in Myanmar, except for Mawlamyine, was consistent with clinical-parasitological efficacy in semi-immune people. High sensitivity to artemisinin compounds was observed in this geographical region. The data suggest that highly mefloquine-resistant P. falciparum is concentrated in a part of the Thai-Myanmar border region.


This article has been cited by other articles:


Home page
 Antimicrob. Agents Chemother.Home page
D. J. Bacon, C. Latour, C. Lucas, O. Colina, P. Ringwald, and S. Picot
Comparison of a SYBR Green I-Based Assay with a Histidine-Rich Protein II Enzyme-Linked Immunosorbent Assay for In Vitro Antimalarial Drug Efficacy Testing and Application to Clinical Isolates
Antimicrob. Agents Chemother., April 1, 2007; 51(4): 1172 - 1178.
[Abstract] [Full Text] [PDF]

Home page
 Antimicrob. Agents Chemother.Home page
A. L. Pickard, C. Wongsrichanalai, A. Purfield, D. Kamwendo, K. Emery, C. Zalewski, F. Kawamoto, R. S. Miller, and S. R. Meshnick
Resistance to Antimalarials in Southeast Asia and Genetic Polymorphisms in pfmdr1
Antimicrob. Agents Chemother., August 1, 2003; 47(8): 2418 - 2423.
[Abstract] [Full Text] [PDF]

Home page
 Am J Trop Med HygHome page
H. NOEDL, M. A. FAIZ, E. B. YUNUS, M. R. RAHMAN, M. A. HOSSAIN, R. SAMAD, R. S. MILLER, L. W. PANG, and C. WONGSRICHANALAI
DRUG-RESISTANT MALARIA IN BANGLADESH: AN IN VITRO ASSESSMENT
Am J Trop Med Hyg, February 1, 2003; 68(2): 140 - 142.
[Abstract] [Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Copyright © 2001 by the American Society of Tropical Medicine and Hygiene.