Research Articles

Elimination of lymphocytes, but not eosinophils, by Fas-mediated apoptosis in murine schistosomiasis

Infection with the helminth parasite Schistosoma mansoni is associated with a pathogenic granulomatous response to parasite eggs. Multiple cell types constitute the granuloma with eosinophils achieving numerical dominance. We hypothesize that eosinophil dominance is achieved by selective apoptosis in lymphocytes. We report here that lymphocytes from both the spleens and granulomas of S. mansoni-infected mice undergo apoptosis. We also show that granuloma lymphocytes are more susceptible to Fas-FasL-mediated apoptosis than spleen lymphocytes and this apoptosis may be related to antigen concentration. Conversely, eosinophils from the granuloma and spleens of S. mansoni-infected mice are resistant to apoptosis in vivo and are protected in vitro from Fas-FasL-mediated apoptosis by the absence of FasL expression in the presence of Fas expression. Finally, the apoptotic regulatory molecules Bcl-2, Bcl-xL, and Bax, do not appear to play a significant role in the regulation of eosinophil apoptosis in the schistosome granuloma.

This article has been cited by other articles:

				L. I. Rutitzky, G. A. Mirkin, and M. J. Stadecker Apoptosis by Neglect of CD4+ Th Cells in Granulomas: A Novel Effector Mechanism Involved in the Control of Egg-Induced Immunopathology in Murine Schistosomiasis J. Immunol., August 15, 2003; 171(4): 1859 - 1867. [Abstract] [Full Text] [PDF]

				L. Chen, K. V. N. Rao, Y.-X. He, and K. Ramaswamy Skin-stage Schistosomula of Schistosoma mansoni Produce an Apoptosis-inducing Factor That Can Cause Apoptosis of T Cells J. Biol. Chem., September 6, 2002; 277(37): 34329 - 34335. [Abstract] [Full Text] [PDF]