|
|
||||||||
The diagnosis of iron deficiency anemia in malaria endemic areas is complicated by the influence of the infection on the laboratory tests conventionally used to assess iron status. Determination of soluble transferrin receptor (sTfR) levels has been shown to be a sensitive indicator of iron deficiency in adults and is not affected by a range of infectious and inflammatory conditions. The utility of sTfR levels in the diagnosis of iron deficiency in malaria endemic areas remains unresolved. Three hundred and fourteen infants in a rural area of southern Tanzania living under conditions of intense and perennial malaria transmission were studied to determine the utility of sTfR plasma levels in the assessment of iron deficiency anemia. Independent of the presence of anemia, malaria parasitemia was associated with a significant increase in sTfR plasma levels that were even higher than those found in iron deficiency anemia. We conclude that the measurement of sTfR levels does not have a role in the diagnosis of iron deficiency anemia in young children exposed to malaria infection.
This article has been cited by other articles:
![]() |
C. A Northrop-Clewes Interpreting indicators of iron status during an acute phase response - lessons from malaria and human immunodeficiency virus Ann Clin Biochem, January 1, 2008; 45(1): 18 - 32. [Abstract] [Full Text] [PDF] |
||||
![]() |
M. B Zimmermann, L. Molinari, F. Staubli-Asobayire, S. Y Hess, N. Chaouki, P. Adou, and R. F Hurrell Serum transferrin receptor and zinc protoporphyrin as indicators of iron status in African children Am. J. Clinical Nutrition, March 1, 2005; 81(3): 615 - 623. [Abstract] [Full Text] [PDF] |
||||
![]() |
D. SCHELLENBERG, E. KAHIGWA, S. SANZ, J. J. APONTE, H. MSHINDA, P. ALONSO, and C. MENENDEZ A RANDOMIZED COMPARISON OF TWO ANEMIA TREATMENT REGIMENS IN TANZANIAN CHILDREN Am J Trop Med Hyg, October 1, 2004; 71(4): 428 - 433. [Abstract] [Full Text] [PDF] |
||||
![]() |
C. MENENDEZ, D. SCHELLENBERG, L. QUINTO, E. KAHIGWA, L. ALVAREZ, J. J. APONTE, and P. L. ALONSO THE EFFECTS OF SHORT-TERM IRON SUPPLEMENTATION ON IRON STATUS IN INFANTS IN MALARIA-ENDEMIC AREAS Am J Trop Med Hyg, October 1, 2004; 71(4): 434 - 440. [Abstract] [Full Text] [PDF] |
||||
![]() |
H. Verhoef, C. E West, P. Ndeto, J. Burema, Y. Beguin, and F. J Kok Serum transferrin receptor concentration indicates increased erythropoiesis in Kenyan children with asymptomatic malaria Am. J. Clinical Nutrition, December 1, 2001; 74(6): 767 - 775. [Abstract] [Full Text] |
||||
| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |