AJTMH Transactions of the Royal Society of Tropical Medicine and Hygiene
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     

Am. J. Trop. Med. Hyg., 64(1), 2001, pp. 28-31
Copyright © 2001 by The American Society of Tropical Medicine and Hygiene

This Article
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Right arrow Citation Map
Services
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow reprints & permissions
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Cox-Singh, J
Right arrow Articles by Singh, B
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Cox-Singh, J
Right arrow Articles by Singh, B
Related Collections
Right arrow Genetic Epidemiology
Right arrow Malaria
American Journal of Tropical Medicine and Hygiene, Vol 64, Issue 1, 28-31
Copyright © 2001 by American Society of Tropical Medicine and Hygiene

Research Articles


Short report: differences in dihydrofolate reductase but not dihydropteroate synthase alleles in Plasmodium falciparum isolates from geographically distinct areas in Malaysia

J Cox-Singh, R Zakaria, MS Abdullah, HA Rahman, S Nagappan, and B Singh

Dihydropteroate synthase (dhps) and dihydrofolate reductase (dhfr) alleles were typed in 67 Malaysian Plasmodium falciparum isolates. The isolates were collected from two geographically distinct locations: 51 from Sabah, Malaysian Borneo, where sulfadoxine/pyrimethamine (SDX/PYR) is used to treat uncomplicated malaria and 16 from Peninsular Malaysia where in vivo resistance to SDX/PYR has been reported. A total of seven dhps alleles were identified with no significant difference in allele frequency between the 2 populations. Two of the dhps alleles described here have not been previously reported. Four dhfr alleles were detected in 67 P. falciparum isolates. Eighty-seven percent of the isolates from the Peninsula, where clinical SDX/PYR failure has been reported, had dhfr alleles with triple point mutations while all of the isolates from Sabah had dhfr alleles with 2 or less point mutations. The difference in dhfr allele frequency between the two populations was highly significant. There was no correlation between in vitro PYR response and accumulation of dhfr point mutations.


This article has been cited by other articles:


Home page
 Am J Trop Med HygHome page
N. J. Yatich, J. Yi, T. Agbenyega, A. Turpin, J. C. Rayner, J. K. Stiles, W. O. Ellis, E. Funkhouser, J. E. Ehiri, J. H. Williams, et al.
Malaria and Intestinal Helminth Co-infection Among Pregnant Women in Ghana: Prevalence and Risk Factors
Am J Trop Med Hyg, June 1, 2009; 80(6): 896 - 901.
[Abstract] [Full Text] [PDF]

Home page
 Am J Trop Med HygHome page
D. Naniche, A. Bardaji, M. Lahuerta, A. Berenguera, I. Mandomando, S. Sanz, J. J. Aponte, B. Sigauque, P. L. Alonso, and C. Menendez
Impact of Maternal Human Immunodeficiency Virus Infection on Birth Outcomes and Infant Survival in Rural Mozambique
Am J Trop Med Hyg, May 1, 2009; 80(5): 870 - 876.
[Abstract] [Full Text] [PDF]

Home page
 Am J Trop Med HygHome page
G. I. Msamanga, T. E. Taha, A. M. Young, E. R. Brown, I. F. Hoffman, J. S. Read, V. Mudenda, R. L. Goldenberg, U. Sharma, M. Sinkala, et al.
Placental Malaria and Mother-to-Child Transmission of Human Immunodeficiency Virus-1
Am J Trop Med Hyg, April 1, 2009; 80(4): 508 - 515.
[Abstract] [Full Text] [PDF]

Home page
 Am J Trop Med HygHome page
S. Gies, S. O. Coulibaly, C. Ky, F. T. Ouattara, B. J. Brabin, and U. D'Alessandro
Community-Based Promotional Campaign to Improve Uptake of Intermittent Preventive Antimalarial Treatment in Pregnancy in Burkina Faso
Am J Trop Med Hyg, March 1, 2009; 80(3): 460 - 469.
[Abstract] [Full Text] [PDF]

Home page
 Am J Trop Med HygHome page
S. D. Perrault, J. Hajek, K. Zhong, S. O. Owino, M. Sichangi, G. Smith, Y. P. Shi, J. M. Moore, and K. C. Kain
Human Immunodeficiency Virus Co-Infection Increases Placental Parasite Density and Transplacental Malaria Transmission in Western Kenya
Am J Trop Med Hyg, January 1, 2009; 80(1): 119 - 125.
[Abstract] [Full Text] [PDF]

Home page
 Am J Trop Med HygHome page
S. J. Rogerson, V. Mwapasa, and S. R. Meshnick
Malaria in Pregnancy: Linking Immunity and Pathogenesis to Prevention
Am J Trop Med Hyg, December 1, 2007; 77(6_Suppl): 14 - 22.
[Abstract] [Full Text] [PDF]

Home page
 Am J Trop Med HygHome page
S. O. Coulibaly, S. Gies, and U. D'Alessandro
Malaria Burden Among Pregnant Women Living in the Rural District of Boromo, Burkina Faso
Am J Trop Med Hyg, December 1, 2007; 77(6_Suppl): 56 - 60.
[Abstract] [Full Text] [PDF]

Home page
 Am J Trop Med HygHome page
M. J. Barcus, H. Basri, H. Picarima, C. Manyakori, Sekartuti, I. Elyazar, M. J. Bangs, J. D. Maguire, and J. K. Baird
Demographic Risk Factors for Severe and Fatal Vivax and Falciparum Malaria Among Hospital Admissions in Northeastern Indonesian Papua
Am J Trop Med Hyg, November 1, 2007; 77(5): 984 - 991.
[Abstract] [Full Text] [PDF]

Home page
 Am J Trop Med HygHome page
S. Thapa, J. Hollander, M. Linehan, J. Cox-Singh, M. B. Bista, G. D. Thakur, W. A. Davis, and T. M. E. Davis
Comparison of Artemether-Lumefantrine with Sulfadoxine-Pyrimethamine for the Treatment of Uncomplicated Falciparum Malaria in Eastern Nepal
Am J Trop Med Hyg, September 1, 2007; 77(3): 423 - 430.
[Abstract] [Full Text] [PDF]

Home page
 Am J Trop Med HygHome page
F. K. Parekh, J. N. Hernandez, D. J. Krogstad, W. M. Casapia, and O. H. Branch
Prevalence and Risk of Plasmodium falciparum and P. vivax Malaria among Pregnant Women Living in the Hypoendemic Communities of the Peruvian Amazon
Am J Trop Med Hyg, September 1, 2007; 77(3): 451 - 457.
[Abstract] [Full Text] [PDF]

Home page
 Am J Trop Med HygHome page
G. COTTRELL, J.-Y. MARY, D. BARRO, and M. COT
THE IMPORTANCE OF THE PERIOD OF MALARIAL INFECTION DURING PREGNANCY ON BIRTH WEIGHT IN TROPICAL AFRICA
Am J Trop Med Hyg, May 1, 2007; 76(5): 849 - 854.
[Abstract] [Full Text] [PDF]

Home page
 Antimicrob. Agents Chemother.Home page
F. P. Mockenhaupt, G. Bedu-Addo, C. Junge, L. Hommerich, T. A. Eggelte, and U. Bienzle
Markers of Sulfadoxine-Pyrimethamine-Resistant Plasmodium falciparum in Placenta and Circulation of Pregnant Women
Antimicrob. Agents Chemother., January 1, 2007; 51(1): 332 - 334.
[Abstract] [Full Text] [PDF]

Home page
 Am J Trop Med HygHome page
A. A. ADEGNIKA, J. J. VERWEIJ, S. T. AGNANDJI, S. K. CHAI, L. PH. BREITLING, M. RAMHARTER, M. FROLICH, S. ISSIFOU, P. G. KREMSNER, and M. YAZDANBAKHSH
MICROSCOPIC AND SUB-MICROSCOPIC PLASMODIUM FALCIPARUM INFECTION, BUT NOT INFLAMMATION CAUSED BY INFECTION, IS ASSOCIATED WITH LOW BIRTH WEIGHT
Am J Trop Med Hyg, November 1, 2006; 75(5): 798 - 803.
[Abstract] [Full Text] [PDF]

Home page
 Infect. Immun.Home page
N. Bir, S. S. Yazdani, M. Avril, C. Layez, J. Gysin, and C. E. Chitnis
Immunogenicity of Duffy Binding-Like Domains That Bind Chondroitin Sulfate A and Protection against Pregnancy-Associated Malaria.
Infect. Immun., October 1, 2006; 74(10): 5955 - 5963.
[Abstract] [Full Text] [PDF]

Home page
 Proc. Natl. Acad. Sci. USAHome page
N. Rasti, F. Namusoke, A. Chene, Q. Chen, T. Staalsoe, M.-Q. Klinkert, F. Mirembe, F. Kironde, and M. Wahlgren
Nonimmune immunoglobulin binding and multiple adhesion characterize Plasmodium falciparum-infected erythrocytes of placental origin
PNAS, September 12, 2006; 103(37): 13795 - 13800.
[Abstract] [Full Text] [PDF]

Home page
 Infect. Immun.Home page
M. F. Duffy, A. Caragounis, R. Noviyanti, H. M. Kyriacou, E. K. Choong, K. Boysen, J. Healer, J. A. Rowe, M. E. Molyneux, G. V. Brown, et al.
Transcribed var Genes Associated with Placental Malaria in Malawian Women.
Infect. Immun., August 1, 2006; 74(8): 4875 - 4883.
[Abstract] [Full Text] [PDF]

Home page
 Am J Trop Med HygHome page
S. B. SIRIMA, A. H. COTTE, A. KONATE, A. C. MORAN, K. ASAMOA, E. C. BOUGOUMA, A. DIARRA, A. OUEDRAOGO, M. E. PARISE, and R. D. NEWMAN
MALARIA PREVENTION DURING PREGNANCY: ASSESSING THE DISEASE BURDEN ONE YEAR AFTER IMPLEMENTING A PROGRAM OF INTERMITTENT PREVENTIVE TREATMENT IN KOUPELA DISTRICT, BURKINA FASO.
Am J Trop Med Hyg, August 1, 2006; 75(2): 205 - 211.
[Abstract] [Full Text] [PDF]

Home page
 Am J Trop Med HygHome page
A. ROSS and T. SMITH
THE EFFECT OF MALARIA TRANSMISSION INTENSITY ON NEONATAL MORTALITY IN ENDEMIC AREAS.
Am J Trop Med Hyg, August 1, 2006; 75(2_suppl): 74 - 81.
[Abstract] [Full Text] [PDF]

Home page
 Biol. Reprod.Home page
C. S. Rutland, M. Mukhopadhyay, S. Underwood, N. Clyde, T. M. Mayhew, and C. A. Mitchell
Induction of Intrauterine Growth Restriction by Reducing Placental Vascular Growth with the Angioinhibin TNP-470
Biol Reprod, December 1, 2005; 73(6): 1164 - 1173.
[Abstract] [Full Text] [PDF]

Home page
 J Antimicrob ChemotherHome page
A. Aubouy, S. Jafari, V. Huart, F. Migot-Nabias, J. Mayombo, R. Durand, M. Bakary, J. Le Bras, and P. Deloron
DHFR and DHPS genotypes of Plasmodium falciparum isolates from Gabon correlate with in vitro activity of pyrimethamine and cycloguanil, but not with sulfadoxine-pyrimethamine treatment efficacy
J. Antimicrob. Chemother., July 1, 2003; 52(1): 43 - 49.
[Abstract] [Full Text] [PDF]

Home page
 Infect. Immun.Home page
S. T. Agbor-Enoh, R. N. Achur, M. Valiyaveettil, R. Leke, D. W. Taylor, and D. C. Gowda
Chondroitin Sulfate Proteoglycan Expression and Binding of Plasmodium falciparum-Infected Erythrocytes in the Human Placenta during Pregnancy
Infect. Immun., May 1, 2003; 71(5): 2455 - 2461.
[Abstract] [Full Text] [PDF]

Home page
 J. Nutr.Home page
R. W. Steketee
Pregnancy, Nutrition and Parasitic Diseases
J. Nutr., May 1, 2003; 133(5): 1661S - 1667.
[Abstract] [Full Text] [PDF]

Home page
 J. Clin. Microbiol.Home page
S. J. Rogerson, P. Mkundika, and M. K. Kanjala
Diagnosis of Plasmodium falciparum Malaria at Delivery: Comparison of Blood Film Preparation Methods and of Blood Films with Histology
J. Clin. Microbiol., April 1, 2003; 41(4): 1370 - 1374.
[Abstract] [Full Text] [PDF]

Home page
 J. Immunol.Home page
E. T. Abrams, H. Brown, S. W. Chensue, G. D. H. Turner, E. Tadesse, V. M. Lema, M. E. Molyneux, R. Rochford, S. R. Meshnick, and S. J. Rogerson
Host Response to Malaria During Pregnancy: Placental Monocyte Recruitment Is Associated with Elevated {beta} Chemokine Expression
J. Immunol., March 1, 2003; 170(5): 2759 - 2764.
[Abstract] [Full Text] [PDF]

Home page
 Infect. Immun.Home page
S. J. Rogerson, H. C. Brown, E. Pollina, E. T. Abrams, E. Tadesse, V. M. Lema, and M. E. Molyneux
Placental Tumor Necrosis Factor Alpha but Not Gamma Interferon Is Associated with Placental Malaria and Low Birth Weight in Malawian Women
Infect. Immun., January 1, 2003; 71(1): 267 - 270.
[Abstract] [Full Text] [PDF]

Home page
 Antimicrob. Agents Chemother.Home page
B. Lell and P. G. Kremsner
Clindamycin as an Antimalarial Drug: Review of Clinical Trials
Antimicrob. Agents Chemother., August 1, 2002; 46(8): 2315 - 2320.
[Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Copyright © 2001 by the American Society of Tropical Medicine and Hygiene.