Research Articles

CR1 density polymorphism on erythrocytes of falciparum malaria patients in Thailand

Complement receptor type 1 (CR1) on erythrocytes shows an inherited numerical polymorphism which correlates with a HindIII-RFLP (restriction fragment length polymorphism) of the CR1 gene in various populations. To investigate the relationship between CR1 density polymorphism and disease severity, we typed 185 Thai patients with acute falciparum malaria (55 severe and 130 uncomplicated) for their genotypes of this polymorphism. The level of expression of erythrocyte CR1 from 42 randomly selected patients was measured by enzyme-linked immunosorbent assay (ELISA). We observed a significantly higher frequency of homozygotes of the CR1 low density allele (LL) among the severe group as compared to the uncomplicated group (P = 0.005). CR1 expression on erythrocytes from patients with the LL genotype was significantly lower than homozygotes with the high density allele (HH) (P < 0.0001) and heterozygotes (HL) (P = 0.013). The results suggest that a genetically-determined low CR1 density on erythrocytes may be a risk factor for developing a more severe form of malaria in Thai subjects.

This article has been cited by other articles:

				E. Liebau, K. F. Dawood, R. Fabrini, L. Fischer-Riepe, M. Perbandt, L. Stella, J. Z. Pedersen, A. Bocedi, P. Petrarca, G. Federici, et al. Tetramerization and Cooperativity in Plasmodium falciparum Glutathione S-Transferase Are Mediated by Atypic Loop 113-119 J. Biol. Chem., August 14, 2009; 284(33): 22133 - 22139. [Abstract] [Full Text] [PDF]

				G. Dhangadamajhi, B. N. Mohapatra, S. K. Kar, and M. Ranjit Endothelial Nitric Oxide Synthase Gene Polymorphisms and Plasmodium falciparum Infection in Indian Adults Infect. Immun., July 1, 2009; 77(7): 2943 - 2947. [Abstract] [Full Text] [PDF]

				R. Jurgelenaite, T. M. H. Dijkstra, C. H. M. Kocken, and T. Heskes Gene regulation in the intraerythrocytic cycle of Plasmodium falciparum Bioinformatics, June 15, 2009; 25(12): 1484 - 1491. [Abstract] [Full Text] [PDF]

				S. J. Jordan, O. H. Branch, J. C. Castro, R. A. Oster, and J. C. Rayner Genetic Diversity of the Malaria Vaccine Candidate Plasmodium falciparum Merozoite Surface Protein-3 in a Hypoendemic Transmission Environment Am J Trop Med Hyg, March 1, 2009; 80(3): 479 - 486. [Abstract] [Full Text] [PDF]

				Z. Holland, R. Prudent, J.-B. Reiser, C. Cochet, and C. Doerig Functional Analysis of Protein Kinase CK2 of the Human Malaria Parasite Plasmodium falciparum Eukaryot. Cell, March 1, 2009; 8(3): 388 - 397. [Abstract] [Full Text] [PDF]

				F. Fillol, A. Cournil, D. Boulanger, B. Cisse, C. Sokhna, G. Targett, J.-F. Trape, F. Simondon, B. Greenwood, and K. B. Simondon Influence of Wasting and Stunting at the Onset of the Rainy Season on Subsequent Malaria Morbidity among Rural Preschool Children in Senegal Am J Trop Med Hyg, February 1, 2009; 80(2): 202 - 208. [Abstract] [Full Text] [PDF]

				A. A. Siddiqui, H. Bora, N. Singh, A. P. Dash, and Y. D. Sharma Expression, Purification, and Characterization of the Immunological Response to a 40-Kilodalton Plasmodium vivax Tryptophan-Rich Antigen Infect. Immun., June 1, 2008; 76(6): 2576 - 2586. [Abstract] [Full Text] [PDF]

				M. Niikura, S. Kamiya, K. Kita, and F. Kobayashi Coinfection with Nonlethal Murine Malaria Parasites Suppresses Pathogenesis Caused by Plasmodium berghei NK65 J. Immunol., May 15, 2008; 180(10): 6877 - 6884. [Abstract] [Full Text] [PDF]

				M. Ditzen, M. Pellegrino, and L. B. Vosshall Insect Odorant Receptors Are Molecular Targets of the Insect Repellent DEET Science, March 28, 2008; 319(5871): 1838 - 1842. [Abstract] [Full Text] [PDF]

				M. F. Somi, J. R. G. Butler, F. Vahid, J. Njau, S. P. Kachur, and S. Abdulla Is There Evidence for Dual Causation Between Malaria and Socioeconomic Status? Findings From Rural Tanzania Am J Trop Med Hyg, December 1, 2007; 77(6): 1020 - 1027. [Abstract] [Full Text] [PDF]

				S. Gwer, C. R.J.C. Newton, and J. A. Berkley Over-Diagnosis and Co-Morbidity of Severe Malaria in African Children: A Guide for Clinicians Am J Trop Med Hyg, December 1, 2007; 77(6_Suppl): 6 - 13. [Abstract] [Full Text] [PDF]

				J. G. Breman and C. N. Holloway Malaria Surveillance Counts Am J Trop Med Hyg, December 1, 2007; 77(6_Suppl): 36 - 47. [Abstract] [Full Text] [PDF]

				A. Kumar, N. Valecha, T. Jain, and A. P. Dash Burden of Malaria in India: Retrospective and Prospective View Am J Trop Med Hyg, December 1, 2007; 77(6_Suppl): 69 - 78. [Abstract] [Full Text] [PDF]

				A. A. Bawah and F. N. Binka How Many Years of Life Could Be Saved If Malaria Were Eliminated from a Hyperendemic Area of Northern Ghana? Am J Trop Med Hyg, December 1, 2007; 77(6_Suppl): 145 - 152. [Abstract] [Full Text] [PDF]

				C. Guinovart and P. L. Alonso Methods for Determining Vaccine Efficacy and Effectiveness and the Main Barriers to Developing a Fully Deployable Malaria Vaccine Am J Trop Med Hyg, December 1, 2007; 77(6_Suppl): 276 - 281. [Abstract] [Full Text] [PDF]

				I. Ssewanyana, C. Pietras, C. A. Baker, F. Nghania, N. G. Jones, P. J. Rosenthal, G. Dorsey, and H. Cao Pattern of Malaria-specific T-Cell Responses in a Cohort of Ugandan Children J Trop Pediatr, November 4, 2007; (2007) fmm061v1. [Abstract] [Full Text] [PDF]

				F. Teuscher, J. Lowther, T. S. Skinner-Adams, T. Spielmann, M. W. A. Dixon, C. M. Stack, S. Donnelly, A. Mucha, P. Kafarski, S. Vassiliou, et al. The M18 Aspartyl Aminopeptidase of the Human Malaria Parasite Plasmodium falciparum J. Biol. Chem., October 19, 2007; 282(42): 30817 - 30826. [Abstract] [Full Text] [PDF]

				E. L. Dahl and P. J. Rosenthal Multiple Antibiotics Exert Delayed Effects against the Plasmodium falciparum Apicoplast Antimicrob. Agents Chemother., October 1, 2007; 51(10): 3485 - 3490. [Abstract] [Full Text] [PDF]

				F. P. Mockenhaupt, K. Reither, P. Zanger, F. Roepcke, I. Danquah, E. Saad, P. Ziniel, S. Y. Dzisi, M. Frempong, P. Agana-Nsiire, et al. Intermittent Preventive Treatment in Infants as a Means of Malaria Control: a Randomized, Double-Blind, Placebo-Controlled Trial in Northern Ghana Antimicrob. Agents Chemother., September 1, 2007; 51(9): 3273 - 3281. [Abstract] [Full Text] [PDF]

				A. E. Orimadegun, O. Fawole, J. O. Okereke, F. O. Akinbami, and O. Sodeinde Increasing Burden of Childhood Severe Malaria in a Nigerian Tertiary Hospital: Implication for Control J Trop Pediatr, June 1, 2007; 53(3): 185 - 189. [Abstract] [Full Text] [PDF]

				R. L. HINTON, A. AUWUN, G. PONGUA, O. OA, T. M. E. DAVIS, H. A. KARUNAJEEWA, and J. C. REEDER CAREGIVERS' ACCEPTANCE OF USING ARTESUNATE SUPPOSITORIES FOR TREATING CHILDHOOD MALARIA IN PAPUA NEW GUINEA Am J Trop Med Hyg, April 1, 2007; 76(4): 634 - 640. [Abstract] [Full Text] [PDF]

				A. Kumar, K. Kumar, R. Korde, S. K. Puri, P. Malhotra, and V. Singh Chauhan Falcipain-1, a Plasmodium falciparum Cysteine Protease with Vaccine Potential Infect. Immun., April 1, 2007; 75(4): 2026 - 2034. [Abstract] [Full Text] [PDF]

				K. D. Augustijn, R. Kleemann, J. Thompson, T. Kooistra, C. E. Crawford, S. E. Reece, A. Pain, A. H. G. Siebum, C. J. Janse, and A. P Waters Functional Characterization of the Plasmodium falciparum and P. berghei Homologues of Macrophage Migration Inhibitory Factor Infect. Immun., March 1, 2007; 75(3): 1116 - 1128. [Abstract] [Full Text] [PDF]

				C. Dobano, S. J. Rogerson, T. E. Taylor, J. S. McBride, and M. E. Molyneux Expression of Merozoite Surface Protein Markers by Plasmodium falciparum-Infected Erythrocytes in Peripheral Blood and Tissues of Children with Fatal Malaria Infect. Immun., February 1, 2007; 75(2): 643 - 652. [Abstract] [Full Text] [PDF]

				G. L. GENRICH, J. GUARNER, C. D. PADDOCK, W.-J. SHIEH, P. W. GREER, J. W. BARNWELL, and S. R. ZAKI FATAL MALARIA INFECTION IN TRAVELERS: NOVEL IMMUNOHISTOCHEMICAL ASSAYS FOR THE DETECTION OF PLASMODIUM FALCIPARUM IN TISSUES AND IMPLICATIONS FOR PATHOGENESIS Am J Trop Med Hyg, February 1, 2007; 76(2): 251 - 259. [Abstract] [Full Text] [PDF]

				P. J. RATHNAM, J. P. BRYAN, and M. WOLFE EPIDEMIOLOGY OF MALARIA AMONG UNITED STATES GOVERNMENT PERSONNEL ASSIGNED TO DIPLOMATIC POSTS Am J Trop Med Hyg, February 1, 2007; 76(2): 260 - 266. [Abstract] [Full Text] [PDF]

				S. W. Shin, G. Bian, and A. S. Raikhel A Toll Receptor and a Cytokine, Toll5A and Spz1C, Are Involved in Toll Antifungal Immune Signaling in the Mosquito Aedes aegypti J. Biol. Chem., December 22, 2006; 281(51): 39388 - 39395. [Abstract] [Full Text] [PDF]

				M. J. ELIADES, A. WOLKON, K. MORGAH, S. B. CRAWFORD, A. DORKENOO, Y. SODAHLON, W. A. HAWLEY, A. W. HIGHTOWER, F. O. T. KUILE, and D. J. TERLOUW Burden of malaria at community level in children less than 5 years of age in togo. Am J Trop Med Hyg, October 1, 2006; 75(4): 622 - 629. [Abstract] [Full Text] [PDF]

				K Bae and K-N Jeon CT findings of malarial spleen. Br. J. Radiol., October 1, 2006; 79(946): e145 - e147. [Abstract] [Full Text] [PDF]

				E. L. Dahl, J. L. Shock, B. R. Shenai, J. Gut, J. L. DeRisi, and P. J. Rosenthal Tetracyclines Specifically Target the Apicoplast of the Malaria Parasite Plasmodium falciparum. Antimicrob. Agents Chemother., September 1, 2006; 50(9): 3124 - 3131. [Abstract] [Full Text] [PDF]

				T. SMITH, A. ROSS, N. MAIRE, C. ROGIER, J.-F. TRAPE, and L. MOLINEAUX AN EPIDEMIOLOGIC MODEL OF THE INCIDENCE OF ACUTE ILLNESS IN PLASMODIUM FALCIPARUM MALARIA. Am J Trop Med Hyg, August 1, 2006; 75(2_suppl): 56 - 62. [Abstract] [Full Text] [PDF]

				E. M. Pasini, M. Kirkegaard, P. Mortensen, H. U. Lutz, A. W. Thomas, and M. Mann In-depth analysis of the membrane and cytosolic proteome of red blood cells Blood, August 1, 2006; 108(3): 791 - 801. [Abstract] [Full Text] [PDF]

				J. A. STOUTE, D. G. HEPPNER JR., C. J. MASON, J. SIANGLA, M. O. OPOLLO, K. E. KESTER, L. VIGNERON, G. VOSS, M. J. WALTER, N. TORNIEPORTH, et al. Phase 1 safety and immunogenicity trial of malaria vaccine rts,s/as02a in adults in a hyperendemic region of Western kenya. Am J Trop Med Hyg, July 1, 2006; 75(1): 166 - 170. [Abstract] [Full Text] [PDF]

				G. A. Biagini, P. Viriyavejakul, P. M. O'Neill, P. G. Bray, and S. A. Ward Functional Characterization and Target Validation of Alternative Complex I of Plasmodium falciparum Mitochondria. Antimicrob. Agents Chemother., May 1, 2006; 50(5): 1841 - 1851. [Abstract] [Full Text] [PDF]

				A. Jalloh, H. van Thien, M. U. Ferreira, J. Ohashi, H. Matsuoka, T. Kanbe, A. Kikuchi, and F. Kawamoto Sequence Variation in the T-Cell Epitopes of the Plasmodium falciparum Circumsporozoite Protein among Field Isolates Is Temporally Stable: a 5-Year Longitudinal Study in Southern Vietnam J. Clin. Microbiol., April 1, 2006; 44(4): 1229 - 1235. [Abstract] [Full Text] [PDF]

				H. A. Karunajeewa, J. Reeder, K. Lorry, E. Dabod, J. Hamzah, M. Page-Sharp, G. M. Chiswell, K. F. Ilett, and T. M. E. Davis Artesunate Suppositories versus Intramuscular Artemether for Treatment of Severe Malaria in Children in Papua New Guinea Antimicrob. Agents Chemother., March 1, 2006; 50(3): 968 - 974. [Abstract] [Full Text] [PDF]

				G. Bian, S. W. Shin, H.-M. Cheon, V. Kokoza, and A. S. Raikhel Transgenic alteration of Toll immune pathway in the female mosquito Aedes aegypti PNAS, September 20, 2005; 102(38): 13568 - 13573. [Abstract] [Full Text] [PDF]

				K. C. Pandey, S. X. Wang, P. S. Sijwali, A. L. Lau, J. H. McKerrow, and P. J. Rosenthal The Plasmodium falciparum cysteine protease falcipain-2 captures its substrate, hemoglobin, via a unique motif PNAS, June 28, 2005; 102(26): 9138 - 9143. [Abstract] [Full Text] [PDF]

				J. J. Kessl, K. H. Ha, A. K. Merritt, B. B. Lange, P. Hill, B. Meunier, S. R. Meshnick, and B. L. Trumpower Cytochrome b Mutations That Modify the Ubiquinol-binding Pocket of the Cytochrome bc1 Complex and Confer Anti-malarial Drug Resistance in Saccharomyces cerevisiae J. Biol. Chem., April 29, 2005; 280(17): 17142 - 17148. [Abstract] [Full Text] [PDF]

				S. W. Shin, V. Kokoza, G. Bian, H.-M. Cheon, Y. J. Kim, and A. S. Raikhel REL1, a Homologue of Drosophila Dorsal, Regulates Toll Antifungal Immune Pathway in the Female Mosquito Aedes aegypti J. Biol. Chem., April 22, 2005; 280(16): 16499 - 16507. [Abstract] [Full Text] [PDF]

				A. L. Omara-Opyene, P. A. Moura, C. R. Sulsona, J. A. Bonilla, C. A. Yowell, H. Fujioka, D. A. Fidock, and J. B. Dame Genetic Disruption of the Plasmodium falciparum Digestive Vacuole Plasmepsins Demonstrates Their Functional Redundancy J. Biol. Chem., December 24, 2004; 279(52): 54088 - 54096. [Abstract] [Full Text] [PDF]

				D. Bell and P. Winstanley Current issues in the treatment of uncomplicated malaria in Africa Br. Med. Bull., December 13, 2004; 71(1): 29 - 43. [Abstract] [Full Text] [PDF]

				H. J. Vial, S. Wein, C. Farenc, C. Kocken, O. Nicolas, M. L. Ancelin, F. Bressolle, A. Thomas, and M. Calas Prodrugs of bisthiazolium salts are orally potent antimalarials PNAS, October 26, 2004; 101(43): 15458 - 15463. [Abstract] [Full Text] [PDF]

				G. Raso, A. Luginbuhl, C. A Adjoua, N. T Tian-Bi, K. D Silue, B. Matthys, P. Vounatsou, Y. Wang, M.-E. Dumas, E. Holmes, et al. Multiple parasite infections and their relationship to self-reported morbidity in a community of rural Cote d'Ivoire Int. J. Epidemiol., October 1, 2004; 33(5): 1092 - 1102. [Abstract] [Full Text] [PDF]

				A. Singh and P. J. Rosenthal Selection of Cysteine Protease Inhibitor-resistant Malaria Parasites Is Accompanied by Amplification of Falcipain Genes and Alteration in Inhibitor Transport J. Biol. Chem., August 20, 2004; 279(34): 35236 - 35241. [Abstract] [Full Text] [PDF]

				D. L. McFadden and V. Sunkara The educative impact of health care treatment on malarial prevention behavior for the poor in Guinea, West Africa PNAS, August 3, 2004; 101(31): 11523 - 11525. [Abstract] [Full Text] [PDF]

				C. C. John, R. A. O'Donnell, P. O. Sumba, A. M. Moormann, T. F. de Koning-Ward, C. L. King, J. W. Kazura, and B. S. Crabb Evidence That Invasion-Inhibitory Antibodies Specific for the 19-kDa Fragment of Merozoite Surface Protein-1 (MSP-119) Can Play a Protective Role against Blood-Stage Plasmodium falciparum Infection in Individuals in a Malaria Endemic Area of Africa J. Immunol., July 1, 2004; 173(1): 666 - 672. [Abstract] [Full Text] [PDF]

				P. S. Sijwali, K. Kato, K. B. Seydel, J. Gut, J. Lehman, M. Klemba, D. E. Goldberg, L. H. Miller, and P. J. Rosenthal Plasmodium falciparum cysteine protease falcipain-1 is not essential in erythrocytic stage malaria parasites PNAS, June 8, 2004; 101(23): 8721 - 8726. [Abstract] [Full Text] [PDF]

				P. S. Sijwali and P. J. Rosenthal Gene disruption confirms a critical role for the cysteine protease falcipain-2 in hemoglobin hydrolysis by Plasmodium falciparum PNAS, March 30, 2004; 101(13): 4384 - 4389. [Abstract] [Full Text] [PDF]

				M. Perbandt, C. Burmeister, R. D. Walter, C. Betzel, and E. Liebau Native and Inhibited Structure of a Mu class-related Glutathione S-transferase from Plasmodium falciparum J. Biol. Chem., January 9, 2004; 279(2): 1336 - 1342. [Abstract] [Full Text] [PDF]

				I. A. Cockburn, M. J. Mackinnon, A. O'Donnell, S. J. Allen, J. M. Moulds, M. Baisor, M. Bockarie, J. C. Reeder, and J. A. Rowe From The Cover: A human complement receptor 1 polymorphism that reduces Plasmodium falciparum rosetting confers protection against severe malaria PNAS, January 6, 2004; 101(1): 272 - 277. [Abstract] [Full Text] [PDF]

				R. J. Pleass, S. A. Ogun, D. H. McGuinness, J. G. J. van de Winkel, A. A. Holder, and J. M. Woof Novel antimalarial antibodies highlight the importance of the antibody Fc region in mediating protection Blood, December 15, 2003; 102(13): 4424 - 4430. [Abstract] [Full Text] [PDF]

				J. Zhu, L. Chen, and A. S. Raikhel Posttranscriptional control of the competence factor {beta}FTZ-F1 by juvenile hormone in the mosquito Aedes aegypti PNAS, November 11, 2003; 100(23): 13338 - 13343. [Abstract] [Full Text] [PDF]

				A. L. Pickard, C. Wongsrichanalai, A. Purfield, D. Kamwendo, K. Emery, C. Zalewski, F. Kawamoto, R. S. Miller, and S. R. Meshnick Resistance to Antimalarials in Southeast Asia and Genetic Polymorphisms in pfmdr1 Antimicrob. Agents Chemother., August 1, 2003; 47(8): 2418 - 2423. [Abstract] [Full Text] [PDF]

				R. W. Steketee Pregnancy, Nutrition and Parasitic Diseases J. Nutr., May 1, 2003; 133(5): 1661S - 1667. [Abstract] [Full Text] [PDF]

				S. W. Shin, V. Kokoza, I. Lobkov, and A. S. Raikhel Relish-mediated immune deficiency in the transgenic mosquito Aedes aegypti PNAS, March 4, 2003; 100(5): 2616 - 2621. [Abstract] [Full Text] [PDF]

				B. C. Urban and D. J. Roberts Inhibition of T Cell Function During Malaria: Implications for Immunology and Vaccinology J. Exp. Med., January 20, 2003; 197(2): 137 - 141. [Full Text] [PDF]

				I. Caro-Aguilar, A. Rodriguez, J. M. Calvo-Calle, F. Guzman, P. De la Vega, M. Elkin Patarroyo, M. R. Galinski, and A. Moreno Plasmodium vivax Promiscuous T-Helper Epitopes Defined and Evaluated as Linear Peptide Chimera Immunogens Infect. Immun., July 1, 2002; 70(7): 3479 - 3492. [Abstract] [Full Text] [PDF]

				P. S. Sijwali, B. R. Shenai, and P. J. Rosenthal Folding of the Plasmodium falciparum Cysteine Protease Falcipain-2 Is Mediated by a Chaperone-like Peptide and Not the Prodomain J. Biol. Chem., April 19, 2002; 277(17): 14910 - 14915. [Abstract] [Full Text] [PDF]

				G. Garratty, M. J. Telen, and L. D. Petz Red Cell Antigens as Functional Molecules and Obstacles to Transfusion Hematology, January 1, 2002; 2002(1): 445 - 462. [Abstract] [Full Text]