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Am. J. Trop. Med. Hyg., 63(5), 2000, pp. 290-294
Copyright © 2000 by The American Society of Tropical Medicine and Hygiene

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American Journal of Tropical Medicine and Hygiene, Vol 63, Issue 5, 290-294
Copyright © 2000 by American Society of Tropical Medicine and Hygiene

Research Articles


Clinical trial of sequential treatments of moderately severe and severe malaria with dihydroartemisinin suppository followed by mefloquine in Thailand

P Wilairatna, S Krudsood, U Silachamroon, P Singhasivanon, S Vannaphan, S Faithong, M Klabprasit, SN Bangchang, P Olliaro, and S Looareesuwan

One hundred and fifty patients with severe falciparum malaria were administered sequential combination of dihydroartemisinin suppository followed by an oral mefloquine tablet. Dihydroartemisinin suppositories (80 mg/capsule) were given rectally once daily for 3 days with a total dose of 8-10 mg/kg. Two doses of mefloquine, 15 mg/kg/dose and 10 mg/kg/dose, were given at 72 hr and 84 hr, respectively. The mean [SD] parasite clearance time and fever clearance time were 46.1 [15.7] hr and 82.5 [59.6] hr, respectively. No death or major adverse drug effects occurred. The cure rate at 28 days of inpatient follow-up was 95% (113 of 119 patients). In severe malaria, dihydroartemisinin suppository followed by oral mefloquine is a suitable alternative treatment to parenteral drugs.


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H. A. Karunajeewa, L. Manning, I. Mueller, K. F. Ilett, and T. M. E. Davis
Rectal Administration of Artemisinin Derivatives for the Treatment of Malaria
JAMA, June 6, 2007; 297(21): 2381 - 2390.
[Abstract] [Full Text] [PDF]


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