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Am. J. Trop. Med. Hyg., 62(6), 2000, pp. 720-725
Copyright © 2000 by The American Society of Tropical Medicine and Hygiene

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American Journal of Tropical Medicine and Hygiene, Vol 62, Issue 6, 720-725
Copyright © 2000 by American Society of Tropical Medicine and Hygiene

Research Articles


Serologic responses of Korean soldiers serving in malaria-endemic areas during a recent outbreak of Plasmodium vivax

CG Park, YJ Chwae, JI Kim, JH Lee, GM Hur, BH Jeon, JS Koh, JH Han, SJ Lee, JW Park, DC Kaslow, D Strickman, and CS Roh

Anti-Pv200 antibody levels were assessed in samples from endemic areas of Plasmodium vivax malaria in the Republic of Korea (ROK), using an indirect enzyme-linked immunosorbent assay (ELISA) method. Asymptomatic carriers of P. vivax were detected using nested polymerase chain reaction (PCR) of blood samples. Anti-Pv200 antibody levels in 20 vivax malaria patients (optical density +/- standard deviation [OD +/- SD] values 1.85 +/- 0.29 of IgG isotype and 1.33 +/- 1.33 of IgM isotype) were markedly higher than those of uninfected, malaria-naive controls (0.08 +/- 0.16 of IgG isotype and 0.04 +/- 0.04 of IgM isotype). Antibody levels for 7 out of 8 soldiers with a recent malaria infection were sustained above the cut-off values for 4 months after successful treatment. Analysis of serum collected from 40 healthy, asymptomatic soldiers who had a P. vivax malaria attack within 3 months after our sampling, revealed 11 antibody-positive samples (27.5%), compared to 5 positive samples (12.5%) collected from a random selection of 40 soldiers. Among a larger pool of 1,713 soldiers who had served in high-risk areas for P. vivax transmission, 15% were antibody positive. Among 1,000 blood samples from asymptomatic soldiers who had served in the high-risk areas, 4 samples (0.4%) were parasite positive, as determined by nested PCR. Our results show that anti-Pv200 antibody levels can provide useful information in the late diagnosis of P. vivax malaria infection in a previously naive population and also in large seroepidemiologic studies. Furthermore, our results suggest that asymptomatic P. vivax carriers could be important in the current outbreak of malaria in Korea.


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C. SUPHAVILAI, S. LOOAREESUWAN, and M. F. GOOD
ANALYSIS OF CIRCUMSPOROZOITE PROTEIN-SPECIFIC IMMUNE RESPONSES FOLLOWING RECENT INFECTION WITH PLASMODIUM VIVAX
Am J Trop Med Hyg, July 1, 2004; 71(1): 29 - 39.
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Copyright © 2000 by the American Society of Tropical Medicine and Hygiene.