AJTMH Transactions of the Royal Society of Tropical Medicine and Hygiene
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     

Am. J. Trop. Med. Hyg., 62(6), 2000, pp. 693-697
Copyright © 2000 by The American Society of Tropical Medicine and Hygiene

This Article
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow reprints & permissions
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Taylor, W.
Right arrow Articles by Baird, J.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Taylor, W.
Right arrow Articles by Baird, J.
Related Collections
Right arrow Plasmodium
Right arrow Malaria
American Journal of Tropical Medicine and Hygiene, Vol 62, Issue 6, 693-697
Copyright © 2000 by American Society of Tropical Medicine and Hygiene

Research Articles


Assessing drug sensitivity of Plasmodium vivax to halofantrine or choroquine in southern, central Vietnam using an extended 28-day in vivo test and polymerase chain reaction genotyping

WR Taylor, HN Doan, DT Nguyen, TU Tran, DJ Fryauff, E Gomez-Saladin, KC Kain, DC Le, and JK Baird

Chloroquine-resistant Plasmodium vivax malaria is emerging in Oceania, Asia, and Latin America. We assessed the drug sensitivity of P. vivax to chloroquine or halofantrine in two villages in southern, central Vietnam. This area has chloroquine-resistant Plasmodium falciparum but no documented chloroquine-resistant P. vivax. Standard dose chloroquine (25 mg/kg, over 48 hours) or halofantrine (8 mg/kg, 3 doses) was administered to 29 and 25 patients, respectively. End points were parasite sensitivity or resistance determined at 28 days. Of the evaluable patients, 23/23 100% (95% confidence interval [CI] 85.1-100) chloroquine and 21/24 (87.5%) (95% CI 67.6-97.3) halofantrine-treated patients were sensitive. Three halofantrine recipients had initial clearance but subsequent recurrence of their parasitemias. Genotyping of the recurrent and Day 0 parasitemias differed, suggesting either new infections or relapses of liver hypnozoites from antecedent infections. Among these Vietnamese patients, P. vivax was sensitive to chloroquine and halofantrine. Genotyping was useful for differentiating the recurrent vivax parasitemias.


This article has been cited by other articles:


Home page
 Am J Trop Med HygHome page
J. Marfurt, I. Mueller, A. Sie, P. Maku, M. Goroti, J. C. Reeder, H.-P. Beck, and B. Genton
Low Efficacy of Amodiaquine or Chloroquine Plus Sulfadoxine-Pyrimethamine against Plasmodium falciparum and P. vivax Malaria in Papua New Guinea
Am J Trop Med Hyg, November 1, 2007; 77(5): 947 - 954.
[Abstract] [Full Text] [PDF]

Home page
 Am J Trop Med HygHome page
J. A. BONILLA, L. VALIDUM, R. CUMMINGS, and C. J. PALMER
GENETIC DIVERSITY OF PLASMODIUM VIVAX PVCSP AND PVMSP1 IN GUYANA, SOUTH AMERICA
Am J Trop Med Hyg, November 1, 2006; 75(5): 830 - 835.
[Abstract] [Full Text] [PDF]

Home page
 Antimicrob. Agents Chemother.Home page
J. K. Baird
Chloroquine Resistance in Plasmodium vivax
Antimicrob. Agents Chemother., November 1, 2004; 48(11): 4075 - 4083.
[Full Text] [PDF]

Home page
 Am J Trop Med HygHome page
D. H. NHAN, W. R. J. TAYLOR, N. D. THUONG, T. T. UYEN, D. J. FRYAUFF, I. SUSANTI, E. GOMEZ-SALADIN, L. D. CONG, and J. K. BAIRD
SHORT REPORT: IN VIVO SENSITIVITY OF PLASMODIUM FALCIPARUM TO HALOFANTRINE IN SOUTHERN CENTRAL VIETNAM
Am J Trop Med Hyg, November 1, 2003; 69(5): 553 - 554.
[Abstract] [Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Copyright © 2000 by the American Society of Tropical Medicine and Hygiene.