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Am. J. Trop. Med. Hyg., 62(4), 2000, pp. 524-529
Copyright © 2000 by The American Society of Tropical Medicine and Hygiene

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American Journal of Tropical Medicine and Hygiene, Vol 62, Issue 4, 524-529
Copyright © 2000 by American Society of Tropical Medicine and Hygiene

Research Articles


A randomized controlled trial of artemotil (beta-arteether) in Zambian children with cerebral malaria

PE Thuma, GJ Bhat, GF Mabeza, C Osborne, G Biemba, GM Shakankale, PA Peeters, B Oosterhuis, CB Lugt, and VR Gordeuk

The efficacy and safety of intramuscular artemotil (ARTECEF) was compared to intravenous quinine in African children with cerebral malaria. This prospective block randomized open-label study was conducted at two centers in Zambia. Subjects were children aged 0 to 10 years of age with cerebral malaria and a Blantyre Coma Score of 2 or less. Ninety two children were studied; 48 received artemotil and 44 quinine. No significant differences in survival, coma resolution time, neurologic sequelae, parasite clearance time, and fever resolution time were seen between the two regimens. Rates for negative malaria smears one month after therapy were similar in both groups. Artemotil was a well-tolerated drug in the 48 patients in this study. It appears to be at least therapeutically equivalent to quinine for the treatment of pediatric cerebral malaria. It has the advantage of being able to be given intramuscularly once daily for only five days.


This article has been cited by other articles:


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A. PAREEK, A. NANDY, D. KOCHAR, K. H. PATEL, S. K. MISHRA, and P. C. MATHUR
EFFICACY AND SAFETY OF {beta}-ARTEETHER AND {alpha}/{beta}-ARTEETHER FOR TREATMENT OF ACUTE PLASMODIUM FALCIPARUM MALARIA.
Am J Trop Med Hyg, July 1, 2006; 75(1): 139 - 142.
[Abstract] [Full Text] [PDF]

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Q. LI, C. B. LUGT, S. LOOAREESUWAN, S. KRUDSOOD, P. WILAIRATANA, S. VANNAPHAN, K. CHALEARMRULT, and W. K. MILHOUS
PHARMACOKINETIC INVESTIGATION ON THE THERAPEUTIC POTENTIAL OF ARTEMOTIL ({beta}-ARTEETHER) IN THAI PATIENTS WITH SEVERE PLASMODIUM FALCIPARUM MALARIA
Am J Trop Med Hyg, December 1, 2004; 71(6): 723 - 731.
[Abstract] [Full Text] [PDF]


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