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Am. J. Trop. Med. Hyg., 62(4), 2000, pp. 491-495
Copyright © 2000 by The American Society of Tropical Medicine and Hygiene

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American Journal of Tropical Medicine and Hygiene, Vol 62, Issue 4, 491-495
Copyright © 2000 by American Society of Tropical Medicine and Hygiene

Research Articles


Adaptation of a chloroquine-resistant strain of Plasmodium vivax from Indonesia to New World monkeys

WE Collins, JS Sullivan, DJ Fryauff, J Kendall, V Jennings, GG Galland, and CL Morris

The spread of chloroquine-resistant Plasmodium vivax from Papua New Guinea and Indonesia poses a serious health threat to areas of Southeast Asia where this species of malaria parasite is endemic. A strain of P. vivax from Indonesia was adapted to develop in splenectomized Aotus lemurinus griseimembra, Aotus vociferans, Aotus nancymai, and Saimiri boliviensis monkeys. Transmission to splenectomized Saimiri monkeys was obtained via sporozoites. Chemotherapeutic studies indicated that the strain was resistant to chloroquine and amodiaquine while sensitive to mefloquine. Infections of chloroquine-resistant P.vivax in New World monkeys should be useful for the development of alternative treatments.


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