AJTMH Tropical Medicine and Hygiene News
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     

Am. J. Trop. Med. Hyg., 62(2), 2000, pp. 284-290
Copyright © 2000 by The American Society of Tropical Medicine and Hygiene

This Article
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Right arrow Citation Map
Services
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow reprints & permissions
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Dobbie, M
Right arrow Articles by Surtees, R
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Dobbie, M
Right arrow Articles by Surtees, R
Related Collections
Right arrow Malaria
Right arrow Plasmodium
American Journal of Tropical Medicine and Hygiene, Vol 62, Issue 2, 284-290
Copyright © 2000 by American Society of Tropical Medicine and Hygiene

Research Articles


Cerebrospinal fluid studies in children with cerebral malaria: an excitotoxic mechanism?

M Dobbie, J Crawley, C Waruiru, K Marsh, and R Surtees

The pathogenesis of cerebral malaria is poorly understood. One hypothesis is that activation of microglia and astrocytes in the brain might cause the cerebral symptoms by excitotoxic mechanisms. Cerebrospinal fluid was sampled in 97 Kenyan children with cerebral malaria, 85% within 48 hr of admission. When compared with an age-matched reference range, there were large increases in concentrations of the excitotoxin quinolinic acid (geometric mean ratio cerebral malaria/reference population [95% confidence limits] = 14.1 [9.8-20.4], P < 0.001) and total neopterin (10.9 [9.1-13.0], P < 0.001) and lesser increases in tetra-hydrobiopterin, di-hydrobiopterin, and 5-hydroxyindoleacetic acid. There was no change in tryptophan concentration. In contrast, nitrate plus nitrite concentrations were decreased (geometric mean ratio = 0.45 [0.35-0.59], P < 0.001). There was a graded increment in quinolinic acid concentration across outcome groups of increasing severity. The increased concentration of quinolinic acid suggests that excitotoxic mechanisms may contribute to the pathogenesis of cerebral malaria.


This article has been cited by other articles:


Home page
 Infect. Immun.Home page
B. K. Lopansri, N. M. Anstey, G. J. Stoddard, E. D. Mwaikambo, C. S. Boutlis, E. Tjitra, H. Maniboey, M. R. Hobbs, M. C. Levesque, J. B. Weinberg, et al.
Elevated plasma phenylalanine in severe malaria and implications for pathophysiology of neurological complications.
Infect. Immun., June 1, 2006; 74(6): 3355 - 3359.
[Abstract] [Full Text] [PDF]

Home page
 Infect. Immun.Home page
C. J. Clark, G. M. Mackay, G. A. Smythe, S. Bustamante, T. W. Stone, and R. S. Phillips
Prolonged Survival of a Murine Model of Cerebral Malaria by Kynurenine Pathway Inhibition
Infect. Immun., August 1, 2005; 73(8): 5249 - 5251.
[Abstract] [Full Text] [PDF]

Home page
 Clin. Microbiol. Rev.Home page
R. B. Rock, G. Gekker, S. Hu, W. S. Sheng, M. Cheeran, J. R. Lokensgard, and P. K. Peterson
Role of Microglia in Central Nervous System Infections
Clin. Microbiol. Rev., October 1, 2004; 17(4): 942 - 964.
[Abstract] [Full Text] [PDF]

Home page
 Clin. Microbiol. Rev.Home page
I. A. Clark, L. M. Alleva, A. C. Mills, and W. B. Cowden
Pathogenesis of Malaria and Clinically Similar Conditions
Clin. Microbiol. Rev., July 1, 2004; 17(3): 509 - 539.
[Abstract] [Full Text] [PDF]

Home page
 FASEB J.Home page
C. RAE, J. A. MCQUILLAN, S. B. PAREKH, W. A. BUBB, S. WEISER, V. J. BALCAR, A. M. HANSEN, H. J. BALL, and N. H. HUNT
Brain gene expression, metabolism, and bioenergetics: interrelationships in murine models of cerebral and noncerebral malaria
FASEB J, March 1, 2004; 18(3): 499 - 510.
[Abstract] [Full Text] [PDF]

Home page
 ASH Education BookHome page
D. J. Weatherall, L. H. Miller, D. I. Baruch, K. Marsh, O. K. Doumbo, C. Casals-Pascual, and D. J. Roberts
Malaria and the Red Cell
Hematology, January 1, 2002; 2002(1): 35 - 57.
[Abstract] [Full Text]

Home page
 Arch. Dis. Child.Home page
F J Kirkham
Non-traumatic coma in children
Arch. Dis. Child., October 1, 2001; 85(4): 303 - 312.
[Full Text] [PDF]

Home page
 Arch. Dis. Child.Home page
J Crawley, S Smith, P Muthinji, K Marsh, and F Kirkham
Electroencephalographic and clinical features of cerebral malaria
Arch. Dis. Child., March 1, 2001; 84(3): 247 - 253.
[Abstract] [Full Text]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Copyright © 2000 by the American Society of Tropical Medicine and Hygiene.