Research Articles

Short report: study on the efficacy of a new long-acting formulation of N, N-diethyl-m-toluamide (DEET) for the prevention of tick attachment

The beneficial effects of N, N-diethyl-m-toluamide (DEET) against biting insects of human and animals appear to last <6 hr after a single application to the skin. To prolong the repellent effects of DEET, recently we developed a new long-acting formulation of DEET called LIPODEET. This preparation was retained in the skin for a longer duration of time with minimal systemic absorption. In this study, we have evaluated the protective effect of three compounds (DEET, LIPODEET, and Morpel 220) against attachment of two species of ticks (Amblyomma americanum and Dermacentor variabilis) to rabbit ears. Results show that LIPODEET and Morpel 220 were highly effective in preventing tick attachment to the skin for a longer duration of time (up to 72 hr) than DEET after a single application. Moreover, LIPODEET was found to be acaricidal to both the species of ticks.

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				B. Fei and J. H. Xin N, N-diethyl-m-toluamide-Containing Microcapsules for Bio-Cloth Finishing Am J Trop Med Hyg, July 1, 2007; 77(1): 52 - 57. [Abstract] [Full Text] [PDF]

				D. M. Elston Human infestation by larval Amblyomma ticks. Arch Dermatol, April 1, 2006; 142(4): 497 - 500. [Full Text] [PDF]