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Am. J. Trop. Med. Hyg., 61(6), 1999, pp. 994-1000
Copyright © 1999 by The American Society of Tropical Medicine and Hygiene

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American Journal of Tropical Medicine and Hygiene, Vol 61, Issue 6, 994-1000
Copyright © 1999 by American Society of Tropical Medicine and Hygiene

Research Articles


Detection and genetic relationship of dengue virus sequences in seventeen-year-old paraffin-embedded samples from Cuba

CA Sariol, JL Pelegrino, A Martinez, E Arteaga, G Kouri, and MG Guzman

This study describes the use of the reverse transcriptase-polymerase chain reaction (RT-PCR) to generate dengue 2 amplicons from paraffin-embedded autopsy tissues collected in Cuba 17 years ago. The presumptive diagnoses had been made only by clinical evolution without serologic confirmation. This study confirms once again that dengue 2 virus was directly associated with the fatal cases in children and illustrates the potential of the RT-PCR for retrospective diagnosis of dengue cases 17 years after death. A close similarity in the genomic sequences of the dengue 2 RNA detected in tissue samples from fatal cases and those dengue 2 Cuban strains that had been previously investigated confirms the appropriate genomic classification of the etiologic agent associated with the 1981 dengue hemorrhagic fever Cuban epidemic.


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Copyright © 1999 by the American Society of Tropical Medicine and Hygiene.