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Am. J. Trop. Med. Hyg., 61(6), 1999, pp. 964-967
Copyright © 1999 by The American Society of Tropical Medicine and Hygiene

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American Journal of Tropical Medicine and Hygiene, Vol 61, Issue 6, 964-967
Copyright © 1999 by American Society of Tropical Medicine and Hygiene

Research Articles


No evidence of cardiotoxicity during antimalarial treatment with artemether-lumefantrine

M van Vugt, F Ezzet, F Nosten, I Gathmann, P Wilairatana, S Looareesuwan, and NJ White

Artemether-lumefantrine is a new fixed antimalarial combination effective against multidrug-resistant falciparum malaria. A prospective electrocardiographic study was conducted in 150 patients receiving artemetherlumefantrine and 50 treated with artesunate-mefloquine. There was no evidence for clinically significant changes in the electrocardiographic intervals and in particular no relationship between plasma concentrations of lumefantrine and QTc prolongation. Artemether-lumefantrine does not have significant cardiac effects at therapeutic doses.


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Copyright © 1999 by the American Society of Tropical Medicine and Hygiene.