AJTMH Transactions of the Royal Society of Tropical Medicine and Hygiene
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Am. J. Trop. Med. Hyg., 61(6), 1999, pp. 960-963
Copyright © 1999 by The American Society of Tropical Medicine and Hygiene

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Right arrow Leishmaniasis
American Journal of Tropical Medicine and Hygiene, Vol 61, Issue 6, 960-963
Copyright © 1999 by American Society of Tropical Medicine and Hygiene

Research Articles


Response of cutaneous leishmaniasis (chiclero's ulcer) to treatment with meglumine antimoniate in Southeast Mexico

A Vargas-Gonzalez, SB Canto-Lara, AG Damian-Centeno, and FJ Andrade-Narvaez

Cutaneous leishmaniasis, known as chiclero's ulcer in southeastern Mexico, is characterized by a predominantly single, painless, ulcerated lesion, without lymphangitis or adenopathy. When located on the ear, it tends to become chronic, causing destruction of the pinna and disfigurement. It is caused predominantly by Leishmania (L.) mexicana. Although pentavalent antimonials (Sb5+) are the mainstay of leishmanial therapy and have been used for more than 50 years, dosage regimens have been repeatedly modified and the best one has not been fully identified. The main purpose of the present study was to investigate the response of chiclero's ulcer to treatment with meglumine antimoniate. One hundred five patients were treated with meglumine antimoniate at a daily dose of 1 ampule per day (425 mg of Sb5+) until healing. The lesions healed after a mean of 25 days (range = 5-60 days).


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D. VAN DER VLIET, A.-S. LE GUERN, S. FREITAG, N. GOUNOD, A. THERBY, H. DARIE, and P. A. BUFFET
Pseudomonas aeruginosa otochondritis complicating localized cutaneous leishmaniasis: prevention of mutilation by early antibiotic therapy.
Am J Trop Med Hyg, August 1, 2006; 75(2): 270 - 272.
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Copyright © 1999 by the American Society of Tropical Medicine and Hygiene.