| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
|
|
|
|||||||
|
|||||||||
Autopsy tissues from 18 children believed to have died of dengue hemorrhagic fever were tested for the presence of dengue virus RNA by reverse transcription-polymerase chain reaction (RT-PCR). Such RNA was found in 14 of 18 liver specimens, 13 of 18 spleen specimens and 7 of 16 mesenteric lymph node specimens. No dengue virus RNA was detected in 44 samples of brain tissue from 15 individuals, 1 or more of whose other tissues yielded such RNA. All tissues had been tested previously for dengue virus by mosquito inoculation. In those tests, virus was recovered from 5 of 18 liver and 2 of 18 spleen specimens. Thus, the RT-PCR is more sensitive than the most sensitive virus isolation technique for detecting dengue virus or its components in human tissue. Failure to isolate virus from most of spleen and all mesenteric lymph node specimens may indicate that those tissues contained primarily degraded virus undergoing inactivation.
This article has been cited by other articles:
|
|
 |
|
  T. R. Prestwood, D. M. Prigozhin, K. L. Sharar, R. M. Zellweger, and S. Shresta A Mouse-Passaged Dengue Virus Strain with Reduced Affinity for Heparan Sulfate Causes Severe Disease in Mice by Establishing Increased Systemic Viral Loads J. Virol., September 1, 2008; 82(17): 8411 - 8421. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 R. V. Warke, A. Becerra, A. Zawadzka, D. J. Schmidt, K. J. Martin, K. Giaya, J. H. Dinsmore, M. Woda, G. Hendricks, T. Levine, et al. Efficient dengue virus (DENV) infection of human muscle satellite cells upregulates type I interferon response genes and differentially modulates MHC I expression on bystander and DENV-infected cells J. Gen. Virol., July 1, 2008; 89(7): 1605 - 1615. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 C. W. Davis, L. M. Mattei, H.-Y. Nguyen, C. Ansarah-Sobrinho, R. W. Doms, and T. C. Pierson The Location of Asparagine-linked Glycans on West Nile Virions Controls Their Interactions with CD209 (Dendritic Cell-specific ICAM-3 Grabbing Nonintegrin) J. Biol. Chem., December 1, 2006; 281(48): 37183 - 37194. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J.-P. Chen, H.-L. Lu, S.-L. Lai, G. S. Campanella, J.-M. Sung, M.-Y. Lu, B. A. Wu-Hsieh, Y.-L. Lin, T. E. Lane, A. D. Luster, et al. Dengue Virus Induces Expression of CXC Chemokine Ligand 10/IFN-{gamma}-Inducible Protein 10, Which Competitively Inhibits Viral Binding to Cell Surface Heparan Sulfate. J. Immunol., September 1, 2006; 177(5): 3185 - 3192. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
Y.-W. Lin, K.-J. Wang, H.-Y. Lei, Y.-S. Lin, T.-M. Yeh, H.-S. Liu, C.-C. Liu, and S.-H. Chen Virus Replication and Cytokine Production in Dengue Virus-Infected Human B Lymphocytes J. Virol., October 25, 2002; 76(23): 12242 - 12249. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. M. B. Moreno-Altamirano, F. J. Sanchez-Garcia, and M. L. Munoz Non Fc receptor-mediated infection of human macrophages by dengue virus serotype 2 J. Gen. Virol., May 1, 2002; 83(5): 1123 - 1130. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. E. Blaney Jr., D. H. Johnson, C.-Y. Firestone, C. T. Hanson, B. R. Murphy, and S. S. Whitehead Chemical Mutagenesis of Dengue Virus Type 4 Yields Mutant Viruses Which Are Temperature Sensitive in Vero Cells or Human Liver Cells and Attenuated in Mice J. Virol., October 15, 2001; 75(20): 9731 - 9740. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
L.-J. Ho, J.-J. Wang, M.-F. Shaio, C.-L. Kao, D.-M. Chang, S.-W. Han, and J.-H. Lai Infection of Human Dendritic Cells by Dengue Virus Causes Cell Maturation and Cytokine Production J. Immunol., February 1, 2001; 166(3): 1499 - 1506. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. S. Diamond, D. Edgil, T. G. Roberts, B. Lu, and E. Harris Infection of Human Cells by Dengue Virus Is Modulated by Different Cell Types and Viral Strains J. Virol., September 1, 2000; 74(17): 7814 - 7823. [Abstract] [Full Text]
|
|
| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
