AJTMH ASTMH MEMBERSHIP INFORMATION: astmh@astmh.org
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     

Am. J. Trop. Med. Hyg., 61(5), 1999, pp. 694-697
Copyright © 1999 by The American Society of Tropical Medicine and Hygiene

This Article
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow reprints & permissions
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Walsh, D.
Right arrow Articles by Walsh, G.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Walsh, D.
Right arrow Articles by Walsh, G.
Related Collections
Right arrow Zoonotic Diseases
Right arrow Epidemiology
Right arrow Mycobacterial Infections
American Journal of Tropical Medicine and Hygiene, Vol 61, Issue 5, 694-697
Copyright © 1999 by American Society of Tropical Medicine and Hygiene

Research Articles


Transmission of Mycobacterium ulcerans to the nine-banded armadillo

DS Walsh, WM Meyers, RE Krieg, and GP Walsh

Animal models for Mycobacterium ulcerans infections (Buruli ulcer) include guinea pigs, rats, and mice, but each has limitations in replicating the spectrum of human disease. Here, 19 adult nine-banded armadillos were inoculated intradermally with M. ulcerans. Injection sites were examined and skin samples obtained for histologic and microbiology studies. Necropsies were conducted to assess systemic involvement. In group 1 (n = 4), 2 animals developed progressive skin ulcers with undermined borders at the injection sites within 6-10 weeks. Biopsies showed features similar to human disease including extensive necrosis in the deep dermis and subcutaneous fat, mixed cellular infiltrates, and acid-fast bacilli (AFB). In group 2 (n = 15), 5 animals developed progressive skin ulcers, 3 had evanescent papulo-nodules, 3 died shortly after inoculation of unknown causes, and 4 showed no signs of infection. Lesion samples from 3 animals with progressive ulcers were culture positive for AFB. Our findings indicate that nine-banded armadillos are susceptible to M. ulcerans and may develop cutaneous lesions that closely mimic Buruli ulcer.


This article has been cited by other articles:


Home page
 Am J Trop Med HygHome page
D. S. WALSH, E. C. DELA CRUZ, R. M. ABALOS, E. V. TAN, G. P. WALSH, F. PORTAELS, and W. M. MEYERS
CLINICAL AND HISTOLOGIC FEATURES OF SKIN LESIONS IN A CYNOMOLGUS MONKEY EXPERIMENTALLY INFECTED WITH MYCOBACTERIUM ULCERANS (BURULI ULCER) BY INTRADERMAL INOCULATION
Am J Trop Med Hyg, January 1, 2007; 76(1): 132 - 134.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Pathol.Home page
M. Goto, K. Nakanaga, T. Aung, T. Hamada, N. Yamada, M. Nomoto, S. Kitajima, N. Ishii, S. Yonezawa, and H. Saito
Nerve Damage in Mycobacterium ulcerans-Infected Mice: Probable Cause of Painlessness in Buruli Ulcer
Am. J. Pathol., March 1, 2006; 168(3): 805 - 811.
[Abstract] [Full Text] [PDF]

Home page
 Infect. Immun.Home page
M. S. Oliveira, A. G. Fraga, E. Torrado, A. G. Castro, J. P. Pereira, A. L. Filho, F. Milanezi, F. C. Schmitt, W. M. Meyers, F. Portaels, et al.
Infection with Mycobacterium ulcerans Induces Persistent Inflammatory Responses in Mice
Infect. Immun., October 1, 2005; 73(10): 6299 - 6310.
[Abstract] [Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Copyright © 1999 by the American Society of Tropical Medicine and Hygiene.