AJTMH Transactions of the Royal Society of Tropical Medicine and Hygiene
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Am. J. Trop. Med. Hyg., 61(3), 1999, pp. 446-448
Copyright © 1999 by The American Society of Tropical Medicine and Hygiene

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American Journal of Tropical Medicine and Hygiene, Vol 61, Issue 3, 446-448
Copyright © 1999 by American Society of Tropical Medicine and Hygiene

Research Articles


Short report: effects of pyronaridine on gametocytes in patients with acute uncomplicated falciparum malaria

P Ringwald, FS Meche, and LK Basco

The effects of pyronaridine and chloroquine on mature Plasmodium falciparum gametocytes were compared in 161 patients treated with chloroquine or pyronaridine. Neither pyronaridine nor chloroquine showed gametocytocidal activity. The relative risks of post-treatment gametocytemia after pyronaridine and chloroquine treatment in the presence of chloroquine-resistant isolates were 1.25 and 11.5, respectively, suggesting that the use of chloroquine was associated with a high risk of favoring post-therapeutic gametocytemia in chloroquine-resistant infections.


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Transmission-blocking activities of quinine, primaquine, and artesunate.
Antimicrob. Agents Chemother., June 1, 2006; 50(6): 1927 - 1930.
[Abstract] [Full Text] [PDF]


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