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Am. J. Trop. Med. Hyg., 61(2), 1999, pp. 325-330
Copyright © 1999 by The American Society of Tropical Medicine and Hygiene

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American Journal of Tropical Medicine and Hygiene, Vol 61, Issue 2, 325-330
Copyright © 1999 by American Society of Tropical Medicine and Hygiene

Research Articles


Natural rodent host associations of Guanarito and pirital viruses (Family Arenaviridae) in central Venezuela

CF Fulhorst, MD Bowen, RA Salas, G Duno, A Utrera, TG Ksiazek, NM De Manzione, E De Miller, C Vasquez, CJ Peters, and RB Tesh

The objective of this study was to elucidate the natural rodent host relationships of Guanarito and Pirital viruses (family Arenaviridae) in the plains of central Venezuela. Ninety-two arenavirus isolates from 607 animals, representing 10 different rodent species, were characterized to the level of serotype. The 92 isolates comprised 19 Guanarito virus strains and 73 Pirital virus strains. The 19 Guanarito virus isolates were from Zygodontomys brevicauda; 72 (98.6%) of the 73 Pirital virus isolates were from Sigmodon alstoni. These results indicate that the natural rodent associations of these 2 sympatric arenaviruses are highly specific and that Z brevicauda and S. alstoni are the principal rodent hosts of Guanarito and Pirital viruses, respectively.


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