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Am. J. Trop. Med. Hyg., 61(2), 1999, pp. 240-244
Copyright © 1999 by The American Society of Tropical Medicine and Hygiene

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American Journal of Tropical Medicine and Hygiene, Vol 61, Issue 2, 240-244
Copyright © 1999 by American Society of Tropical Medicine and Hygiene

Research Articles


Plasmodium falciparum mdr1 mutations and in vivo chloroquine resistance in Indonesia

E Gomez-Saladin, DJ Fryauff, WR Taylor, BS Laksana, AI Susanti, Purnomo, B Subianto, and TL Richie

Mutations in the Pfmdr1 gene are reported to be associated with chloroquine resistance in some Plasmodium falciparum isolates. A polymerase chain reaction/restriction fragment length polymorphism method was used for the detection of Pfmdr1 mutations in chloroquine-resistant field isolates of P. falciparum collected in Irian Jaya. The frequency of Pfmdr1 mutations was significantly higher in chloroquine-resistant P. falciparum parasites than background frequencies observed in the same location. The 7G8 mutation was identified in some parasites although always in a mixed genotype status. Chloroquine-resistant P. falciparum specimens were characterized using the World Health Organization 28-day criteria, supplemented by demonstrating adequate chloroquine absorption and genetic analysis.


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