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Am. J. Trop. Med. Hyg., 61(2), 1999, pp. 198-206
Copyright © 1999 by The American Society of Tropical Medicine and Hygiene

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American Journal of Tropical Medicine and Hygiene, Vol 61, Issue 2, 198-206
Copyright © 1999 by American Society of Tropical Medicine and Hygiene

Research Articles


Clinical analysis and parasite genetic diversity in human immunodeficiency virus/Chagas' disease coinfections in Brazil

L Perez-Ramirez, C Barnabe, AM Sartori, MS Ferreira, JE Tolezano, EV Nunes, MK Burgarelli, AC Silva, MA Shikanai-Yasuda, JN Lima, AM Da-Cruz, OC Oliveira, C Guilherme, B Bastrenta, and M Tibayrenc

To evaluate the possible role of parasitemia on Chagas' disease reactivation in Chagas' disease/human immunodeficiency virus (HIV) coinfection cases and the impact of HIV coinfection on Trypanosoma cruzi genetic diversity, 71 patients with Chagas' disease (34 HIV+ and 37 HIV-) were surveyed. Moreover, 92 T. cruzi stocks from 47 chronic chagasic patients (29 HIV+ and 18 HIV-) were isolated and analyzed by multilocus enzyme electrophoresis and a random amplified polymorphic DNA procedure. High parasitemia appeared to play a major role in cases of Chagas' disease reactivation. In HIV+ patients, the genetic diversity and population structure (clonality) of T. cruzi was similar to that previously observed in HIV- patients, which indicates that immunodepression does not modify drastically genotype repartition of the parasite. There was no apparent association between given T. cruzi genotypes and specific clinical forms of Chagas' disease/HIV associations.


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J. M. BURGOS, S. B. BEGHER, J. M. FREITAS, M. BISIO, T. DUFFY, J. ALTCHEH, R. TEIJEIRO, H. LOPEZ ALCOBA, F. DECCARLINI, H. FREILIJ, et al.
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