AJTMH ASTMH Job Mart
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     

Am. J. Trop. Med. Hyg., 60(6), 1999, pp. 932-935
Copyright © 1999 by The American Society of Tropical Medicine and Hygiene

This Article
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Right arrow Citation Map
Services
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow reprints & permissions
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Ismail, M
Right arrow Articles by Bennett, J.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Ismail, M
Right arrow Articles by Bennett, J.
Related Collections
Right arrow Schistosomiasis
American Journal of Tropical Medicine and Hygiene, Vol 60, Issue 6, 932-935
Copyright © 1999 by American Society of Tropical Medicine and Hygiene

Research Articles


Resistance to praziquantel: direct evidence from Schistosoma mansoni isolated from Egyptian villagers

M Ismail, S Botros, A Metwally, S William, A Farghally, LF Tao, TA Day, and JL Bennett

Recent evidence suggest that resistance to praziquantel (PZQ) may be developing. This would not be surprising in countries like Egypt where the drug has been used aggressively for more that 10 years. The classic phenotype of drug resistance is a significant increase in the 50% effective dose value of isolates retrieved from patients not responding to the drug. In a previous publication, we reported that such phenotypes have been isolated from humans infected with Schistosoma mansoni. Since the action of PZQ may be dependent upon the drug and host factors, most notably the immune system, we analyzed the quantitative effects of PZQ on single worms that differed in their response to PZQ when maintained in mice. Our hypothesis was that the in vitro action of the drug would correlate with it in vivo action. We confirmed this hypothesis and conclude that the in vitro action of the drug is related to its in vivo action. Knowing this relationship will assist in our ability to detect or survey for the PZQ resistant phenotype in human populations.


This article has been cited by other articles:


Home page
 Am J Trop Med HygHome page
D. ALONSO, J. MUNOZ, J. GASCON, M. E. VALLS, and M. CORACHAN
FAILURE OF STANDARD TREATMENT WITH PRAZIQUANTEL IN TWO RETURNED TRAVELERS WITH SCHISTOSOMA HAEMATOBIUM INFECTION
Am J Trop Med Hyg, February 1, 2006; 74(2): 342 - 344.
[Abstract] [Full Text] [PDF]

Home page
 Proc. Natl. Acad. Sci. USAHome page
A. U. Rao, L. K. Carta, E. Lesuisse, and I. Hamza
Lack of heme synthesis in a free-living eukaryote
PNAS, March 22, 2005; 102(12): 4270 - 4275.
[Abstract] [Full Text] [PDF]

Home page
 Clin Med ResHome page
P. M. Neal
Schistosomiasis - An Unusual Cause of Ureteral Obstruction: A Case History and Perspective
Clin. Med. Res., November 1, 2004; 2(4): 216 - 227.
[Abstract] [Full Text] [PDF]

Home page
 Infect. Immun.Home page
P. A. E. Abreu, P. A. Miyasato, M. M. Vilar, W. O. Dias, P. L. Ho, M. Tendler, and A. L. T. O. Nascimento
Sm14 of Schistosoma mansoni in Fusion with Tetanus Toxin Fragment C Induces Immunoprotection against Tetanus and Schistosomiasis in Mice
Infect. Immun., October 1, 2004; 72(10): 5931 - 5937.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
Kelvin. C. Agboh, T. E. Webb, R. J. Evans, and S. J. Ennion
Functional Characterization of a P2X Receptor from Schistosoma mansoni
J. Biol. Chem., October 1, 2004; 279(40): 41650 - 41657.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
J. E. Humphries, M. J. Kimber, Y.-W. Barton, W. Hsu, N. J. Marks, B. Greer, P. Harriott, A. G. Maule, and T. A. Day
Structure and Bioactivity of Neuropeptide F from the Human Parasites Schistosoma mansoni and Schistosoma japonicum
J. Biol. Chem., September 17, 2004; 279(38): 39880 - 39885.
[Abstract] [Full Text] [PDF]

Home page
 Am J Trop Med HygHome page
S. BOTROS, S. WILLIAM, F. EBEID, D. CIOLI, N. KATZ, T. A. DAY, and J. L. BENNETT
LACK OF EVIDENCE FOR AN ANTISCHISTOSOMAL ACTIVITY OF MYRRH IN EXPERIMENTAL ANIMALS
Am J Trop Med Hyg, August 1, 2004; 71(2): 206 - 210.
[Abstract] [Full Text] [PDF]

Home page
 FASEB J.Home page
G. R. MAIR, M. J. NICIU, M. T. STEWART, G. BRENNAN, H. OMAR, D. W. HALTON, R. MAINS, B. A. EIPPER, A. G. MAULE, and T. A. DAY
A functionally atypical amidating enzyme from the human parasite Schistosoma mansoni
FASEB J, January 1, 2004; 18(1): 114 - 121.
[Abstract] [Full Text] [PDF]

Home page
 Antimicrob. Agents Chemother.Home page
S. Botros, S. William, O. Hammam, Z. Zidek, and A. Holy
Activity of 9-(S)-[3-Hydroxy-2-(Phosphonomethoxy)Propyl]Adenine against Schistosomiasis mansoni in Mice
Antimicrob. Agents Chemother., December 1, 2003; 47(12): 3853 - 3858.
[Abstract] [Full Text] [PDF]

Home page
 Antimicrob. Agents Chemother.Home page
J. Utzinger, J. Keiser, X. Shuhua, M. Tanner, and B. H. Singer
Combination Chemotherapy of Schistosomiasis in Laboratory Studies and Clinical Trials
Antimicrob. Agents Chemother., May 1, 2003; 47(5): 1487 - 1495.
[Full Text] [PDF]

Home page
 NEJMHome page
A. G.P. Ross, P. B. Bartley, A. C. Sleigh, G. R. Olds, Y. Li, G. M. Williams, and D. P. McManus
Schistosomiasis
N. Engl. J. Med., April 18, 2002; 346(16): 1212 - 1220.
[Full Text] [PDF]

Home page
 Clin. Microbiol. Rev.Home page
S. Geerts and B. Gryseels
Drug Resistance in Human Helminths: Current Situation and Lessons from Livestock
Clin. Microbiol. Rev., April 1, 2000; 13(2): 207 - 222.
[Abstract] [Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Copyright © 1999 by the American Society of Tropical Medicine and Hygiene.