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Am. J. Trop. Med. Hyg., 60(6), 1999, pp. 921-926
Copyright © 1999 by The American Society of Tropical Medicine and Hygiene

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American Journal of Tropical Medicine and Hygiene, Vol 60, Issue 6, 921-926
Copyright © 1999 by American Society of Tropical Medicine and Hygiene

Research Articles


Genetic analysis of susceptibility to infection with Ascaris lumbricoides

S Williams-Blangero, J Subedi, RP Upadhayay, DB Manral, DR Rai, B Jha, ES Robinson, and J Blangero

Epidemiologic studies of helminthic infections have shown that susceptibility to these parasites frequently aggregates in families, suggesting the possible involvement of genetic factors. This paper presents a genetic epidemiologic analysis of Ascaris lumbricoides infection in the Jirel population of eastern Nepal. A total of 1,261 individuals belonging to a single pedigree were assessed for intensity of Ascaris infection at two time points. Following an initial assessment in which all individuals were treated with albendazole, a follow-up examination was performed one year later to evaluate reinfection patterns. Three measures of worm burden were analyzed, including eggs per gram of feces, direct worm counts, and worm biomass (weight). For all traits, variance component analysis of the familial data provided unequivocal evidence for a strong genetic component accounting for between 30% and 50% of the variation in worm burden. Shared environmental (i.e., common household) effects account for between 3% and 13% of the total phenotypic variance.


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LOW HERITABLE COMPONENT OF RISK FOR INFECTION INTENSITY AND INFECTION-ASSOCIATED DISEASE IN URINARY SCHISTOSOMIASIS AMONG WADIGO VILLAGE POPULATIONS IN COAST PROVINCE, KENYA
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Ascaris lumbricoides Infection Is Associated with Increased Risk of Childhood Asthma and Atopy in Rural China
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Genes on chromosomes 1 and 13 have significant effects on Ascaris infection
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Copyright © 1999 by the American Society of Tropical Medicine and Hygiene.