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Am. J. Trop. Med. Hyg., 60(6), 1999, pp. 1061-1062
Copyright © 1999 by The American Society of Tropical Medicine and Hygiene

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Right arrow Schistosomiasis
American Journal of Tropical Medicine and Hygiene, Vol 60, Issue 6, 1061-1062
Copyright © 1999 by American Society of Tropical Medicine and Hygiene

Research Articles


Short report: prevention of Schistosoma mansoni infections in mice by the insect repellents AI3-37220 and N,N-diethyl-3-methylbenzamide

WE Secor, Freeman GL Jr, and RA Wirtz

N,N-diethyl-3-methylbenzamide (DEET) has recently been reported to kill cercariae of Schistosoma mansoni in vitro. In addition, it blocked cercarial entry into mouse tail skin. We confirmed these results and compared the efficacy of DEET to a second insect repellent, 1-(3-Cyclohexen-1-yl-carbonyl)-2-methylpiperidine (AI3-37220), in preventing S. mansoni infections in mice. Both AI3-37220 and DEET conferred 100% protection against S. mansoni infection via percutaneous exposure to cercariae.




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Copyright © 1999 by the American Society of Tropical Medicine and Hygiene.