| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
|
|
|
|||||||
|
|||||||||
Southeast Asian ovalocytosis (SAO) occurs at high frequency in malarious regions of the western Pacific and may afford a survival advantage against malaria. It is caused by a deletion of the erythrocyte membrane band 3 gene and the band 3 protein mediates the cytoadherence of parasitized erythrocytes in vitro. The SAO band 3 variant may prevent cerebral malaria but it exacerbates malaria anemia and may also increase acidosis, a major determinant of mortality in malaria. We undertook a case-control study of children admitted to hospital in a malarious region of Papua New Guinea. The SAO band 3, detected by the polymerase chain reaction, was present in 0 of 68 children with cerebral malaria compared with six (8.8%) of 68 matched community controls (odds ratio = 0, 95% confidence interval = 0-0.85). Median hemoglobin levels were 1.2 g/dl lower in malaria cases with SAO than in controls (P = 0.035) but acidosis was not affected. The remarkable protection that SAO band 3 affords against cerebral malaria may offer a valuable approach to a better understanding of the mechanisms of adherence of parasitized erythrocytes to vascular endothelium, and thus of the pathogenesis of cerebral malaria.
This article has been cited by other articles:
|
|
 |
|
  C. M. Cserti and W. H. Dzik The ABO blood group system and Plasmodium falciparum malaria Blood, October 1, 2007; 110(7): 2250 - 2258. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 A. O'DONNELL, A. RAIKO, J. B. CLEGG, D. J. WEATHERALL, and S. J. ALLEN SOUTHEAST ASIAN OVALOCYTOSIS AND PREGNANCY IN A MALARIA-ENDEMIC REGION OF PAPUA NEW GUINEA Am J Trop Med Hyg, April 1, 2007; 76(4): 631 - 633. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 G. Min-Oo, A. Fortin, G. Pitari, M. Tam, M. M. Stevenson, and P. Gros Complex genetic control of susceptibility to malaria: positional cloning of the Char9 locus J. Exp. Med., March 19, 2007; 204(3): 511 - 524. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 E. Lin, T. Pappenfuss, R. B. Tan, D. Senyschyn, M. Bahlo, T. P. Speed, and S. J. Foote Mapping of the Plasmodium chabaudi Resistance Locus char2. Infect. Immun., October 1, 2006; 74(10): 5814 - 5819. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
L. J. KASEHAGEN, I. MUELLER, D. T. McNAMARA, M. J. BOCKARIE, B. KINIBORO, L. RARE, K. LORRY, W. KASTENS, J. C. REEDER, J. W. KAZURA, et al. Changing patterns of Plasmodium blood-stage infections in the wosera region of papua new Guinea monitored by light microscopy and high throughput PCR diagnosis. Am J Trop Med Hyg, October 1, 2006; 75(4): 588 - 596. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. BENET, T. Y. KHONG, A. URA, R. SAMEN, K. LORRY, M. MELLOMBO, L. TAVUL, K. BAEA, S. J. ROGERSON, and A. CORTES PLACENTAL MALARIA IN WOMEN WITH SOUTH-EAST ASIAN OVALOCYTOSIS. Am J Trop Med Hyg, October 1, 2006; 75(4): 597 - 604. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
H. IMRIE, F. J.I. FOWKES, P. MICHON, L. TAVUL, J. C.C. HUME, K. P. PIPER, J. C. REEDER, and K. P. DAY HAPTOGLOBIN LEVELS ARE ASSOCIATED WITH HAPTOGLOBIN GENOTYPE AND {alpha}+-THALASSEMIA IN A MALARIA-ENDEMIC AREA Am J Trop Med Hyg, June 1, 2006; 74(6): 965 - 971. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
D. SYAFRUDDIN, P. B. S. ASIH, F. N. COUTRIER, L. TRIANTY, R. NOVIYANTI, Y. LUASE, W. SUMARTO, M. CALEY, A. J.A.M. VAN DER VEN, and R. W. SAUERWEIN MALARIA IN WANOKAKA AND LOLI SUB-DISTRICTS, WEST SUMBA DISTRICT, EAST NUSA TENGGARA PROVINCE, INDONESIA. Am J Trop Med Hyg, May 1, 2006; 74(5): 733 - 737. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. Cortes, A. Benet, B. M. Cooke, J. W. Barnwell, and J. C. Reeder Ability of Plasmodium falciparum to invade Southeast Asian ovalocytes varies between parasite lines Blood, November 1, 2004; 104(9): 2961 - 2966. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 I. A. Cockburn, M. J. Mackinnon, A. O'Donnell, S. J. Allen, J. M. Moulds, M. Baisor, M. Bockarie, J. C. Reeder, and J. A. Rowe From The Cover: A human complement receptor 1 polymorphism that reduces Plasmodium falciparum rosetting confers protection against severe malaria PNAS, January 6, 2004; 101(1): 272 - 277. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 R. Carter and K. N. Mendis Evolutionary and Historical Aspects of the Burden of Malaria Clin. Microbiol. Rev., October 1, 2002; 15(4): 564 - 594. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 A. Fortin, M.M. Stevenson, and P. Gros Susceptibility to malaria as a complex trait: big pressure from a tiny creature Hum. Mol. Genet., October 1, 2002; 11(20): 2469 - 2478. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 A. G. Evans and T. E. Wellems Coevolutionary Genetics of Plasmodium Malaria Parasites and Their Human Hosts Integr. Comp. Biol., April 1, 2002; 42(2): 401 - 407. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 D. J. Weatherall, L. H. Miller, D. I. Baruch, K. Marsh, O. K. Doumbo, C. Casals-Pascual, and D. J. Roberts Malaria and the Red Cell Hematology, January 1, 2002; 2002(1): 35 - 57. [Abstract] [Full Text]
|
|
|
|
|
|
S. S. Patel, R. K. Mehlotra, W. Kastens, C. S. Mgone, J. W. Kazura, and P. A. Zimmerman The association of the glycophorin C exon 3 deletion with ovalocytosis and malaria susceptibility in the Wosera, Papua New Guinea Blood, December 1, 2001; 98(12): 3489 - 3491. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 D. A. P. Evans, H. L. McLeod, S. Pritchard, M. Tariq, and A. Mobarek Interethnic Variability in Human Drug Responses Drug Metab. Dispos., April 1, 2001; 29(4): 606 - 610. [Abstract] [Full Text]
|
|
| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
