AJTMH Transactions of the Royal Society of Tropical Medicine and Hygiene
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     

Am. J. Trop. Med. Hyg., 60(4), 1999, pp. 587-592
Copyright © 1999 by The American Society of Tropical Medicine and Hygiene

This Article
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Right arrow Citation Map
Services
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow reprints & permissions
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Leal-Herrera, Y
Right arrow Articles by Munoz, O
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Leal-Herrera, Y
Right arrow Articles by Munoz, O
Related Collections
Right arrow Helicobacter
American Journal of Tropical Medicine and Hygiene, Vol 60, Issue 4, 587-592
Copyright © 1999 by American Society of Tropical Medicine and Hygiene

Research Articles


Serologic IgG response to urease in Helicobacter pylori-infected persons from Mexico

Y Leal-Herrera, J Torres, G Perez-Perez, A Gomez, T Monath, R Tapia-Conyer, and O Munoz

Helicobacter pylori urease is required to counteract acidity during colonization of the stomach, and has been suggested as a major immunodominant antigen. The aim of this study was to determine the anti-urease response in a representative national serologic survey in Mexico. The population surveyed included persons 1-90 years of age from all socioeconomic levels and geographic zones of the country. Helicobacter pylori status was determined by ELISA serology. The IgG anti-urease was studied by ELISA using a recombinant apoenzyme. We found that 2,930 of the 7,720 infected patients (38%) were seropositive for IgG urease. The rate of IgG anti-urease positivity increased with age; in children < 10 years old it was < 20% and in persons > 40 years old it was > 50%. Age and a region with a high level of development were risk factors for seropositivity, whereas gender, educational level, crowding, and socioeconomic level were not associated with seropositivity. In conclusion, in natural infection with H. pylori, the response to urease is poor, mainly during the first years of infection. This inconsistent immune response to the enzyme may favor persistence of infection. A vaccine eliciting a consistent anti-urease response might overcome immune evasion and enhance clearance of bacteria after exposure.


This article has been cited by other articles:


Home page
 Cancer Epidemiol. Biomarkers Prev.Home page
S. Y. Chui, T. M. Clay, H. K. Lyerly, and M. A. Morse
The Development of Therapeutic and Preventive Vaccines for Gastric Cancer and Helicobacter pylori
Cancer Epidemiol. Biomarkers Prev., August 1, 2005; 14(8): 1883 - 1889.
[Abstract] [Full Text] [PDF]

Home page
 CVIHome page
T. T. H. Hoang, C. Bengtsson, D. C. Phung, M. Sorberg, and M. Granstrom
Seroprevalence of Helicobacter pylori Infection in Urban and Rural Vietnam
Clin. Vaccine Immunol., January 1, 2005; 12(1): 81 - 85.
[Abstract] [Full Text] [PDF]

Home page
 CVIHome page
G. Bode, I. Piechotowski, D. Rothenbacher, and H. Brenner
Helicobacter pylori-Specific Immune Responses of Children: Implications for Future Vaccination Strategy
Clin. Vaccine Immunol., September 1, 2002; 9(5): 1126 - 1128.
[Abstract] [Full Text] [PDF]

Home page
 Infect. Immun.Home page
P. Londono-Arcila, D. Freeman, H. Kleanthous, A. M. O'Dowd, S. Lewis, A. K. Turner, E. L. Rees, T. J. Tibbitts, J. Greenwood, T. P. Monath, et al.
Attenuated Salmonella enterica Serovar Typhi Expressing Urease Effectively Immunizes Mice against Helicobacter pylori Challenge as Part of a Heterologous Mucosal Priming-Parenteral Boosting Vaccination Regimen
Infect. Immun., September 1, 2002; 70(9): 5096 - 5106.
[Abstract] [Full Text] [PDF]

Home page
 CVIHome page
J. Torres, M. Camorlinga-Ponce, G. Perez-Perez, L. Munoz, and O. Munoz
Specific Serum Immunoglobulin G Response to Urease and CagA Antigens of Helicobacter pylori in Infected Children and Adults in a Country with High Prevalence of Infection
Clin. Vaccine Immunol., January 1, 2002; 9(1): 97 - 100.
[Abstract] [Full Text] [PDF]

Home page
 Infect. Immun.Home page
K. Hirota, K. Nagata, Y. Norose, S. Futagami, Y. Nakagawa, H. Senpuku, M. Kobayashi, and H. Takahashi
Identification of an Antigenic Epitope in Helicobacter pylori Urease That Induces Neutralizing Antibody Production
Infect. Immun., November 1, 2001; 69(11): 6597 - 6603.
[Abstract] [Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Copyright © 1999 by the American Society of Tropical Medicine and Hygiene.