AJTMH ASTMH Job Mart
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     

Am. J. Trop. Med. Hyg., 60(3), 1999, pp. 469-474
Copyright © 1999 by The American Society of Tropical Medicine and Hygiene

This Article
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow reprints & permissions
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Mungthin, M
Right arrow Articles by Ward, S.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Mungthin, M
Right arrow Articles by Ward, S.
Related Collections
Right arrow Genetic Epidemiology
Right arrow Malaria
Right arrow Plasmodium
American Journal of Tropical Medicine and Hygiene, Vol 60, Issue 3, 469-474
Copyright © 1999 by American Society of Tropical Medicine and Hygiene

Research Articles


Phenotypic and genotypic characteristics of recently adapted isolates of Plasmodium falciparum from Thailand

M Mungthin, PG Bray, and SA Ward

The drug sensitivity characteristics and Plasmodium falciparum pfmdr1 status of five isolates of P. falciparum recently isolated from patients presenting for treatment from the Thailand/Myanmar border have been investigated. The aim of the study was to avoid the criticisms of some earlier studies by focusing on newly collected isolates from a specific geographic location. Three of the isolates studied exhibited clear resistance to chloroquine similar to that observed in the K1 Thai standard isolate obtained in the 1970s, and the other two isolates were of intermediate sensitivity to chloroquine with concentrations of drug that inhibit parasite growth by 50% of 50 and 43 nmol. The sensitivity of all isolates was enhanced by verapamil but we found no clear association between chloroquine sensitivity and gene copy number or intra-allelic variation of pfmdr1. In contrast, clear cross-resistance was seen between mefloquine and halofantrine, with the most sensitive isolates carrying the K1 mutation in pfmdr1.


This article has been cited by other articles:


Home page
 Antimicrob. Agents Chemother.Home page
P. N. Soh, B. Witkowski, D. Olagnier, M.-L. Nicolau, M.-C. Garcia-Alvarez, A. Berry, and F. Benoit-Vical
In Vitro and In Vivo Properties of Ellagic Acid in Malaria Treatment
Antimicrob. Agents Chemother., March 1, 2009; 53(3): 1100 - 1106.
[Abstract] [Full Text] [PDF]

Home page
 Antimicrob. Agents Chemother.Home page
A. L. Pickard, C. Wongsrichanalai, A. Purfield, D. Kamwendo, K. Emery, C. Zalewski, F. Kawamoto, R. S. Miller, and S. R. Meshnick
Resistance to Antimalarials in Southeast Asia and Genetic Polymorphisms in pfmdr1
Antimicrob. Agents Chemother., August 1, 2003; 47(8): 2418 - 2423.
[Abstract] [Full Text] [PDF]

Home page
 Antimicrob. Agents Chemother.Home page
D. P. Mawili-Mboumba, J. F. J. Kun, B. Lell, P. G. Kremsner, and F. Ntoumi
Pfmdr1 Alleles and Response to Ultralow-Dose Mefloquine Treatment in Gabonese Patients
Antimicrob. Agents Chemother., January 1, 2002; 46(1): 166 - 170.
[Abstract] [Full Text] [PDF]

Home page
 Mol. Pharmacol.Home page
A. M. W. Stead, P. G. Bray, I. G. Edwards, H. P. DeKoning, B. C. Elford, P. A. Stocks, and S. A. Ward
Diamidine Compounds: Selective Uptake and Targeting in Plasmodium falciparum
Mol. Pharmacol., April 16, 2001; 59(5): 1298 - 1306.
[Abstract] [Full Text]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Copyright © 1999 by the American Society of Tropical Medicine and Hygiene.