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Am. J. Trop. Med. Hyg., 60(1), 1999, pp. 85-89
Copyright © 1999 by The American Society of Tropical Medicine and Hygiene

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Right arrow Viral Hemorrhagic Fevers
American Journal of Tropical Medicine and Hygiene, Vol 60, Issue 1, 85-89
Copyright © 1999 by American Society of Tropical Medicine and Hygiene

Research Articles


Proinflammatory cytokines and elastase-alpha-1-antitrypsin in Argentine hemorrhagic fever

RF Marta, VS Montero, CE Hack, A Sturk, JI Maiztegui, and FC Molinas

Argentine hemorrhagic fever (AHF) is a disease caused by Junin virus. In the acute phase, patients present hematologic and neurologic involvement with high levels of interferon-alpha and tumor necrosis factor-alpha (TNF-alpha. Nineteen patients with a confirmed diagnosis of AHF were studied: six severe, four moderate and nine mild cases. Serum levels of interleukin-6 (IL-6), IL-6 soluble receptor (IL-6sR), IL-8, IL-10, and elastase-alpha1-antitrypsin complex (E-alpha 1AT) were assayed by ELISAs. Levels of IL-6, IL-8, and IL-10 were high in nine, 12, and 13 patients, respectively, while levels of IL-6sR were high in two patients and low in one patient. Seven patients had increased levels of E-alpha1AT. Significant correlations were found between levels of both IL-8 and IL-10 with those of TNF-alpha as well as between IL-8 and E-alpha 1AT. These data demonstrate activation of pro-inflammatory and anti-inflammatory cytokine pathways, and statistical analysis showed differences among the clinical forms of illness. This study shows that IL-8 plays an essential role in neutrophil activation in AHF patients as demonstrated in other infectious diseases.


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Copyright © 1999 by the American Society of Tropical Medicine and Hygiene.