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An Effective Trichuricide Suitable for Oral Administration¹

Whipworm infections were completely eliminated in 87.5 per cent of patients who were treated orally with a dosage schedule of 200 mg. of dithiazanine three times a day for five days. The cure rate was 71 per cent when a dosage schedule of 200 mg. twice daily was employed. The anthelmintic spectrum of this drug also includes activity against Ascaris lumbricoides. The results of this study indicate that this compound is a very effective trichuricide which is suitable for oral administration.

¹ This investigation was supported in part by research grant E-543(C3) from the National Institute of Allergy and Infectious Diseases, of the National Institutes of Health, Public Health Service.

The drug employed in this study, dithiazanine (compound 01748), was provided by Eli Lilly and Co.

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