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Chemotherapy of Trypanosoma Gambiense and Trypanosoma Rhodesiense Infections in Guinea Pigs with Nitrofurazone

Administration of single doses of nitrofurazone of 50 to 150 mg./kg. I.M. to 32 guinea pigs each infected with one of 11 different strains of T. gambiense cured half the infections and suppressed the rest. The effectiveness of a given dose of nitrofurazone varied with the strain of T. gambiense; infections caused by some strains (E, K, X, or Z) were cured, while infections caused by other strains (M, Q, R, T, U, and Y) were only suppressed. Variable therapeutic results were obtained with infections caused by strain L. Nitrofurazone produced a better therapeutic response in guinea pigs infected with T. gambiense when the drug was administered about a month following the infection than when treatment was initiated three to five months following infection.

Single doses of nitrofurazone were apparently not so effective in subacute T. rhodesiense infections as in chronic T. gambiense infections in guinea pigs. Single doses of nitrofurazone, 50 to 150 mg./kg. I.M., administered to 30 guinea pigs each infected with one of seven different strains of T. rhodesiense were curative in 10 per cent, suppressive in 80 per cent and ineffective in 10 per cent of the animals.