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Am. J. Trop. Med. Hyg., 6(1), 1957, pp. 90-100
Copyright © 1957 by The American Society of Tropical Medicine and Hygiene

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The Use of Erythrocyte Sensitizing Substance in the Diagnosis of Leptospiroses

I. The Sensitized Erythrocyte Agglutination Test1

Dorothy E. McComb, D. J. W. Smith, David L. Coffin, Robert A. MacCready AND R. Shihman Chang
Department of Microbiology Harvard School of Public Health, Boston, Massachusetts, The Laboratory of Microbiology and Pathology, Department of Health and Home Affairs Queensland, Australia and The Angell Memorial Hospital, and the Diagnostic Laboratory, Massachusetts Department of Public Health

A modified method for the extraction of ESS from leptospirae has been developed which yields preparations stable for at least 41 weeks at 4°C. ESS antibody apparently deteriorated on storage at -20°C. for more than 1 to 1.5 years. Good correlation between the SEA and the agglutination-lysis tests were obtained with fresh sera. Unsatisfactory results were obtained with sera shipped from Australia. About 8 per cent of sera sent to the Massachusetts Department of Public Health for various diagnostic tests were positive in the SEA test, the significance of which is not ascertained. Different antibodies are responsible for the SEA and the agglutination-lysis reactions.


1 This work was supported in part by a research grant from the U. S. P. H. S. National Institutes of Health, Division of Research Grants, E553(C), and by a research grant from the Research Laboratories of Chas. Pfizer Co.






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Copyright © 1957 by the American Society of Tropical Medicine and Hygiene.