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Am. J. Trop. Med. Hyg., 6(1), 1957, pp. 101-107
Copyright © 1957 by The American Society of Tropical Medicine and Hygiene

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The Use of Erythrocyte Sensitizing Substance in the Diagnosis of Leptospiroses

II. The Sensitized Erythrocyte Lysis Test1

R. Shihman Chang, D. J. W. Smith, Dorothy E. McComb, C. F. Sharp AND J. I. Tonge
Department of Microbiology, Harvard School of Public Health, Boston, Massachusetts and the Laboratory of Microbiology and Pathology, Department of Health and Home Affairs, Queensland, Australia

The leptospiral sensitized erythrocyte lysis test established the diagnosis in all 40 cases of human leptospiroses. The sero-group specificity of the test was substantiated by the ability of L. pomona ESS to detect human infection caused by L. icterohemorrhagiae, L. canicola, L. pomona, L. hyos, L. australis A, L. australis B, "Robinson", "Kremastos", and "Celledoni". The value of the SEL test in survey studies of past leptospiral infection requires further study.


1 This work was supported in part by a research grant from the U. S. P. H. S. National Institutes of Health, Division of Research Grants, E553(C), and by a research grant from the Research Laboratories of Chas. Pfizer Co.






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Copyright © 1957 by the American Society of Tropical Medicine and Hygiene.