AJTMH HINARI
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     

Am. J. Trop. Med. Hyg., 59(6), 1998, pp. 889-892
Copyright © 1998 by The American Society of Tropical Medicine and Hygiene

This Article
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow reprints & permissions
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Hendrickx, E.
Right arrow Articles by Velez Bernal, I.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Hendrickx, E.
Right arrow Articles by Velez Bernal, I.
Related Collections
Right arrow Leishmaniasis
American Journal of Tropical Medicine and Hygiene, Vol 59, Issue 6, 889-892
Copyright © 1998 by American Society of Tropical Medicine and Hygiene

Research Articles


Lack of efficacy of mefloquine in the treatment of New World cutaneous leishmaniasis in Colombia

EP Hendrickx, SP Agudelo, DL Munoz, JA Puerta, and ID Velez Bernal

In a nonblinded, therapeutic trial conducted in Colombia, 1.25-1.5 grams of mefloquine base given as a single oral dose or as 250 mg a day for 5-6 consecutive days was not efficacious in the treatment of New World cutaneous leishmaniasis. The drug had cured only 30.8 % of patients with leishmaniasis skin lesions by the 10th week after start of therapy as compared with a 27.9% complete cicatrization rate in historical controls treated with placebo tablets and an 86.3% cicatrization rate in historical controls who received meglumine antimoniate, 20 mg/ kg/day intramuscularly for 20 days, with no upper limit to daily dose. It is concluded that a single course treatment with mefloquine is not indicated as monotherapy in the treatment of Colombian cutaneous leishmaniasis primarily due to L. panamensis.


This article has been cited by other articles:


Home page
 J. Clin. Microbiol.Home page
J. R. Ramírez, S. Agudelo, C. Muskus, J. F. Alzate, C. Berberich, D. Barker, and I. D. Velez
Diagnosis of Cutaneous Leishmaniasis in Colombia: the Sampling Site within Lesions Influences the Sensitivity of Parasitologic Diagnosis
J. Clin. Microbiol., October 1, 2000; 38(10): 3768 - 3773.
[Abstract] [Full Text]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Copyright © 1998 by the American Society of Tropical Medicine and Hygiene.