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Am. J. Trop. Med. Hyg., 59(6), 1998, pp. 877-882
Copyright © 1998 by The American Society of Tropical Medicine and Hygiene

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American Journal of Tropical Medicine and Hygiene, Vol 59, Issue 6, 877-882
Copyright © 1998 by American Society of Tropical Medicine and Hygiene

Research Articles


A cocktail of recombinant Onchocerca volvulus antigens for serologic diagnosis with the potential to predict the endemicity of onchocerciasis infection

JE Bradley, BM Atogho, L Elson, GR Stewart, and M Boussinesq

We report here the evaluation of the potential of a serologic test to determine the endemicity of onchocercal infection in hyper, meso, and hypoendemic communities by the detection of antibodies to a cocktail of recombinant antigens. Parasitologic parameters of infection prevalence and intensity were compared with serologic results. Infection prevalence by serology was consistently but not significantly higher than that defined by parasitology. Differences between the communities defined by microfilarial load (CMFL) and a measurement of Onchocerca volvulus-specific antibody levels (serologic index [SI]) were similar. When stratified by age, differences were more significant in the younger age groups. If a sentinel population of 5-15-year-old individuals was used to compare communities, all could be equally ranked by serologic and parasitologic parameters. The SI of the sentinel population gave a better distinction between each community than the SI of the whole and would be sufficiently sensitive to measure the changes in endemicity that would be required for onchocerciasis control programs.


This article has been cited by other articles:


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J A Andrews, W J Bligh, P L Chiodini, J E Bradley, P N Nde, and R Lucius
The role of a recombinant hybrid protein based ELISA for the serodiagnosis of Onchocerca volvulus
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Prevalence of Antibodies to Onchocerca volvulus in Residents of Oaxaca, Mexico, Treated for 10 Years with Ivermectin
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G. E. Guzman, K. Awadzi, N. Opoku, R. B. Narayanan, and H. O. Akuffo
Comparison between the Skin Snip Test and Simple Dot Blot Assay as Potential Rapid Assessment Tools for Onchocerciasis in the Postcontrol Era in Ghana
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Copyright © 1998 by the American Society of Tropical Medicine and Hygiene.