AJTMH Transactions of the Royal Society of Tropical Medicine and Hygiene
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Am. J. Trop. Med. Hyg., 59(5), 1998, pp. 843-845
Copyright © 1998 by The American Society of Tropical Medicine and Hygiene

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American Journal of Tropical Medicine and Hygiene, Vol 59, Issue 5, 843-845
Copyright © 1998 by American Society of Tropical Medicine and Hygiene

Research Articles


Involvement of macrophage scavenger receptors in protection against murine malaria

S Nogami, J Watanabe, K Nakagaki, K Nakata, H Suzuki, H Suzuki, M Fujisawa, T Kodama, and S Kojima

Macrophage scavenger receptor A (MSR-A) deficient mice MSR-A(-/-) were infected by the intraperitoneal injection of the Plasmodium berghei NK65 strain in the erythrocytic stage. The MSR-A(-/-) mice died significantly earlier than the control mice (P=0.060). In the surviving mice, two peaks of parasitemia were observed: the first 5-7 days and the second at 2-3 weeks after infection. Death of all MSR-A(-/-) mice occurred at either peak of parasitemia, suggesting that MSR-A protects mice from severe infection. This model may be useful for the study of molecular mechanisms of macrophage functions in malaria infection.


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