| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
|
|
|
|||||||
|
|||||||||
We have shown previously that in Dielmo, a Senegalese village with intense perennial Plasmodium falciparum transmission, the infection complexity and the distribution of some allelic types harbored by asymptomatic carriers was age-dependent. We report here an investigation of these parameters in Ndiop, a village located 5 km from Dielmo, where malaria is mesoendemic and seasonal, and where immunity is acquired at a very low rate, as indicated by the lifelong distribution of P. falciparum clinical attacks. Blood was collected from 143 and 125 inhabitants, including 122 individuals sampled in both surveys, during two cross-sectional surveys at one-month intervals during the 1994 transmission season. Plasmodium falciparum parasites were genotyped for three polymorphic single copy genes. Genetic diversity was very large, with 17, 43, and nine distinct alleles detected for the merozoite surface protein-1 (MSP-1), MSP-2, and glutamate-rich protein loci, respectively. These figures, similar to those previously observed in Dielmo, indicate that the parasite genetic diversity is not directly related to the inoculation rate, at least in the range of transmission intensity studied here. The complexity of the asymptomatic infections (average number of distinct genotypes per isolate) was more than two-fold lower in Ndiop than in Dielmo and importantly, did not decrease with age. Likewise, the allele distribution was not influenced by age, contrasting with the observations made in Dielmo. This indicates that the number of parasite types per isolate and the influence of age on complexity and allele distribution depend on the level of endemicity, consistent with the interpretation that they reflect acquired anti-parasite immunity.
This article has been cited by other articles:
|
|
 |
|
  B. Greenhouse, C. Dokomajilar, A. Hubbard, P. J. Rosenthal, and G. Dorsey Impact of Transmission Intensity on the Accuracy of Genotyping To Distinguish Recrudescence from New Infection in Antimalarial Clinical Trials Antimicrob. Agents Chemother., September 1, 2007; 51(9): 3096 - 3103. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 H. HOPKINS, W. KAMBALE, M. R. KAMYA, S. G. STAEDKE, G. DORSEY, and P. J. ROSENTHAL COMPARISON OF HRP2- AND pLDH-BASED RAPID DIAGNOSTIC TESTS FOR MALARIA WITH LONGITUDINAL FOLLOW-UP IN KAMPALA, UGANDA Am J Trop Med Hyg, June 1, 2007; 76(6): 1092 - 1097. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 D. J. Conway Molecular Epidemiology of Malaria Clin. Microbiol. Rev., January 1, 2007; 20(1): 188 - 204. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
B. GREENHOUSE, A. MYRICK, C. DOKOMAJILAR, J. M. WOO, E. J. CARLSON, P. J. ROSENTHAL, and G. DORSEY VALIDATION OF MICROSATELLITE MARKERS FOR USE IN GENOTYPING POLYCLONAL PLASMODIUM FALCIPARUM INFECTIONS Am J Trop Med Hyg, November 1, 2006; 75(5): 836 - 842. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. HENRY, I. DIALLO, J. BORDES, S. KA, B. PRADINES, B. DIATTA, P. S. M'BAYE, M. SANE, M. THIAM, P. M. GUEYE, et al. Urban malaria in dakar, senegal: chemosusceptibility and genetic diversity of Plasmodium falciparum isolates. Am J Trop Med Hyg, July 1, 2006; 75(1): 146 - 151. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
E. G. DEMBO, H. T. PHIRI, J. MONTGOMERY, M. E. MOLYNEUX, and S. J. ROGERSON ARE PLASMODIUM FALCIPARUM PARASITES PRESENT IN PERIPHERAL BLOOD GENETICALLY THE SAME AS THOSE SEQUESTERED IN THE TISSUES? Am J Trop Med Hyg, May 1, 2006; 74(5): 730 - 732. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. MYRICK, E. LEEMANN, C. DOKOMAJILAR, H. HOPKINS, G. DORSEY, M. R. KAMYA, and P. J. ROSENTHAL Dynamics of Plasmodium falciparum malaria after sub-optimal therapy in Uganda. Am J Trop Med Hyg, May 1, 2006; 74(5): 758 - 761. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
D. MENARD, M. D. MATSIKA-CLAQUIN, D. DJALLE, F. YAPOU, A. MANIRAKIZA, V. DOLMAZON, J. SARDA, and A. TALARMIN ASSOCIATION OF FAILURES OF SEVEN-DAY COURSES OF ARTESUNATE IN A NON-IMMUNE POPULATION IN BANGUI, CENTRAL AFRICAN REPUBLIC WITH DECREASED SENSITIVITY OF PLASMODIUM FALCIPARUM Am J Trop Med Hyg, September 1, 2005; 73(3): 616 - 621. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. SLATER, M. KIGGUNDU, C. DOKOMAJILAR, M. R. KAMYA, N. BAKYAITA, A. TALISUNA, P. J. ROSENTHAL, and G. DORSEY DISTINGUISHING RECRUDESCENCES FROM NEW INFECTIONS IN ANTIMALARIAL CLINICAL TRIALS: MAJOR IMPACT OF INTERPRETATION OF GENOTYPING RESULTS ON ESTIMATES OF DRUG EFFICACY Am J Trop Med Hyg, August 1, 2005; 73(2): 256 - 262. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
G. M. PAGANOTTI, H. A. BABIKER, D. MODIANO, B. S. SIRIMA, F. VERRA, A. KONATE, A. L. OUEDRAOGO, A. DIARRA, M. J. MACKINNON, M. COLUZZI, et al. GENETIC COMPLEXITY OF PLASMODIUM FALCIPARUM IN TWO ETHNIC GROUPS OF BURKINA FASO WITH MARKED DIFFERENCES IN SUSCEPTIBILITY TO MALARIA Am J Trop Med Hyg, August 1, 2004; 71(2): 173 - 178. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. CATTAMANCHI, D. KYABAYINZE, A. HUBBARD, P. J. ROSENTHAL, and G. DORSEY DISTINGUISHING RECRUDESCENCE FROM REINFECTION IN A LONGITUDINAL ANTIMALARIAL DRUG EFFICACY STUDY: COMPARISON OF RESULTS BASED ON GENOTYPING OF MSP-1, MSP-2, AND GLURP Am J Trop Med Hyg, February 1, 2003; 68(2): 133 - 139. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 A. F. Read and L. H. Taylor The Ecology of Genetically Diverse Infections Science, May 11, 2001; 292(5519): 1099 - 1102. [Abstract] [Full Text]
|
|
| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
