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Am. J. Trop. Med. Hyg., 59(4), 1998, pp. 523-525
Copyright © 1998 by The American Society of Tropical Medicine and Hygiene

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American Journal of Tropical Medicine and Hygiene, Vol 59, Issue 4, 523-525
Copyright © 1998 by American Society of Tropical Medicine and Hygiene

Research Articles


Short report: total serum levels of the nitric oxide derivatives nitrite/nitrate during microfilarial clearance in human filarial disease

S Winkler, I El Menyawi, KF Linnau, and W Graninger

Nitric oxide (NO) has recently been shown to be cytotoxic to both microfilariae and adult Brugia malayi in vitro and in a murine model, as well against Onchocerca lienalis microfilariae in vitro. We studied the kinetics of nitrite/nitrate, both stable end products of NO, by high-pressure liquid chromatography during microfilaricidal chemotherapy in four filariasis (three Loa loa, and one Onchocerca volvulus) patients. High serum levels of nitrite/nitrate were released during microfilarial clearance and sustained elevated levels were observed six months after chemotherapy, suggesting a role of NO in the elimination of microfilariae in human filariasis.


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M. J. Taylor, H. F. Cross, and K. Bilo
Inflammatory Responses Induced by the Filarial Nematode Brugia malayi Are Mediated by Lipopolysaccharide-like Activity from Endosymbiotic Wolbachia Bacteria
J. Exp. Med., April 17, 2000; 191(8): 1429 - 1436.
[Abstract] [Full Text] [PDF]


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