AJTMH ASTMH Job Mart
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     

Am. J. Trop. Med. Hyg., 59(3), 1998, pp. 497-502
Copyright © 1998 by The American Society of Tropical Medicine and Hygiene

This Article
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow reprints & permissions
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Dondorp, A.
Right arrow Articles by White, N.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Dondorp, A.
Right arrow Articles by White, N.
Related Collections
Right arrow Malaria
Right arrow Plasmodium
American Journal of Tropical Medicine and Hygiene, Vol 59, Issue 3, 497-502
Copyright © 1998 by American Society of Tropical Medicine and Hygiene

Research Articles


Nitric oxides in plasma, urine, and cerebrospinal fluid in patients with severe falciparum malaria

AM Dondorp, T Planche, EE de Bel, BJ Angus, KT Chotivanich, K Silamut, JA Romijn, R Ruangveerayuth, FJ Hoek, PA Kager, J Vreeken, and NJ White

It has been suggested that nitric oxide (NO) plays an important role in the pathogenesis of severe falciparum malaria. Since NO has a very short half-life, nitrate and nitrite (NOx) levels, stable metabolites of NO, are used as measures of NO production. We measured plasma NOx levels in 24 adults with severe falciparum malaria on the Thai-Burmese border. After correction for renal function, there was no correlation between plasma NOx levels, or the total amount of NOx excreted in the urine, and disease severity. Plasma NOx levels decreased after the first 48 hr in all patients (P = 0.007), suggesting decreased NO production. The NOx levels in cerebrospinal fluid (CSF) correlated well with plasma NOx levels, but these did not show a correlation with coma depth, and were not significantly different from those in a healthy control group. These findings do not support the hypothesis that excessive NO production contributes to the pathogenesis of severe falciparum malaria. However, local changes in NO production, e.g., in the central nervous system, might not be reflected in the total NOx production or NOx levels in the CSF.


This article has been cited by other articles:


Home page
 Clin. Microbiol. Rev.Home page
I. A. Clark, L. M. Alleva, A. C. Mills, and W. B. Cowden
Pathogenesis of Malaria and Clinically Similar Conditions
Clin. Microbiol. Rev., July 1, 2004; 17(3): 509 - 539.
[Abstract] [Full Text] [PDF]

Home page
 Infect. Immun.Home page
C. S. Boutlis, E. Tjitra, H. Maniboey, M. A. Misukonis, J. R. Saunders, S. Suprianto, J. B. Weinberg, and N. M. Anstey
Nitric Oxide Production and Mononuclear Cell Nitric Oxide Synthase Activity in Malaria-Tolerant Papuan Adults
Infect. Immun., July 1, 2003; 71(7): 3682 - 3689.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Pathol.Home page
S. Serirom, W. H. Raharjo, K. Chotivanich, S. Loareesuwan, P. Kubes, and M. Ho
Anti-Adhesive Effect of Nitric Oxide on Plasmodium falciparum Cytoadherence under Flow
Am. J. Pathol., May 1, 2003; 162(5): 1651 - 1660.
[Abstract] [Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Copyright © 1998 by the American Society of Tropical Medicine and Hygiene.