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Am. J. Trop. Med. Hyg., 59(3), 1998, pp. 457-461
Copyright © 1998 by The American Society of Tropical Medicine and Hygiene

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American Journal of Tropical Medicine and Hygiene, Vol 59, Issue 3, 457-461
Copyright © 1998 by American Society of Tropical Medicine and Hygiene

Research Articles


The 1993 dengue 2 epidemic in North Queensland: a serosurvey and comparison of hemagglutination inhibition with an ELISA

WJ McBride, H Mullner, JT LaBrooy, and I Wronski

An epidemic of dengue type 2 infection occurred in North Queensland during 1992 and 1993. A random serosurvey of 1,000 residents of a population that experienced this epidemic only during 1993 was conducted to determine the proportion of the population at risk for secondary infection in the event of another epidemic with a different serotype. The ability of an ELISA to detect prior exposure to the dengue virus was compared with the hemagglutination inhibition assay. Dengue 2 virus plaque-reduction neutralization assays were performed to evaluate the specificity of the antibody response. Antibodies to dengue virus, or closely related flaviviruses, were detected in 61.9%. Seroprevalence increased with age and correlated well with known previous epidemics in the region. The sensitivity and specificity of the ELISA was 99.2% and 96.2%, respectively. An estimated 26% of the population was infected during the 1993 epidemic.


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J. B. SIQUEIRA, C. M. T. MARTELLI, I. J. MACIEL, R. M. OLIVEIRA, M. G. RIBEIRO, F. P. AMORIM, B. C. MOREIRA, D. D. P. CARDOSO, W. V. SOUZA, and A. L. S. S. ANDRADE
HOUSEHOLD SURVEY OF DENGUE INFECTION IN CENTRAL BRAZIL: SPATIAL POINT PATTERN ANALYSIS AND RISK FACTORS ASSESSMENT
Am J Trop Med Hyg, November 1, 2004; 71(5): 646 - 651.
[Abstract] [Full Text] [PDF]


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Copyright © 1998 by the American Society of Tropical Medicine and Hygiene.