AJTMH Transactions of the Royal Society of Tropical Medicine and Hygiene
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Am. J. Trop. Med. Hyg., 59(3), 1998, pp. 426-430
Copyright © 1998 by The American Society of Tropical Medicine and Hygiene

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Right arrow Leishmaniasis
American Journal of Tropical Medicine and Hygiene, Vol 59, Issue 3, 426-430
Copyright © 1998 by American Society of Tropical Medicine and Hygiene

Research Articles


Anti-leishmanial IgE antibodies: a marker of active disease in visceral leishmaniasis

AM Atta, D'Oliveira, J Correa, ML Atta, RP Almeida, and EM Carvalho

Visceral leishmaniasis (VL) is characterized by a depression of the T helper cell type 1 immune response. Although mRNA expression for interleukin-4 (IL-4) is observed, evidence of the role of this cytokine in the pathogenesis of VL has been lacking. Since IL-4 is involved in IgE synthesis, we measured the total IgE and Leishmania antigen-specific IgE antibody levels in sera from patients with VL. Specific IgE antibodies detected by an ELISA technique after absorbing the sera with purified sheep IgG anti-human IgG were found in all 23 patients with VL and were not detected in subjects with subclinical Leishmania chagasi infection (n = 10), Chagas' disease (n = 10), atopic patients (n = 10), and healthy controls (n = 10). Levels of Leishmania-specific IgE (optical density values) before and after treatment were 0.100 +/- 0.03 (mean +/- SD) and 0.028 +/- 0.002, respectively (P < 0.05). These results indicate that a specific IgE response is useful in the diagnosis of active disease and to evaluate response to treatment.


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