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Am. J. Trop. Med. Hyg., 59(1), 1998, pp. 133-138
Copyright © 1998 by The American Society of Tropical Medicine and Hygiene

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American Journal of Tropical Medicine and Hygiene, Vol 59, Issue 1, 133-138
Copyright © 1998 by American Society of Tropical Medicine and Hygiene

Research Articles


Treatment of chronic Chagas' disease with itraconazole and allopurinol

W Apt, X Aguilera, A Arribada, C Perez, C Miranda, G Sanchez, I Zulantay, P Cortes, J Rodriguez, and D Juri

Four hundred four patients with chronic Chagas' disease were treated with itraconazole (6 mg/kg of body weight/day for 120 days), allopurinol (8.5 mg/kg of body weight/day for 60 days), or with a placebo of pure starch. Patients were monitored over a period of four years by clinical examination, serology, xenodiagnosis, hemoculture, and electrocardiogram. Drug tolerance was good, with only four treatments discontinued due to side effects that subsided after suspension of treatment. Parasitologic cure was evident in 44% of the those treated with allopurinol and 53% of those treated with itraconazole, and the electrocardiographic evaluation showed normalization in 36.5% and 48.2%, respectively, of patients with chronic or recent cardiopathy.


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