AJTMH Transactions of the Royal Society of Tropical Medicine and Hygiene
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Am. J. Trop. Med. Hyg., 58(6), 1998, pp. 780-785
Copyright © 1998 by The American Society of Tropical Medicine and Hygiene

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American Journal of Tropical Medicine and Hygiene, Vol 58, Issue 6, 780-785
Copyright © 1998 by American Society of Tropical Medicine and Hygiene

Research Articles


Prevention of Borrelia burgdorferi transmission in guinea pigs by tick immunity

S Nazario, S Das, AM de Silva, K Deponte, N Marcantonio, JF Anderson, D Fish, E Fikrig, and FS Kantor

We examined the effect of repeated infestation of guinea pigs with Ixodes scapularis on the capacity of ticks to transmit Borrelia burgdorferi infection. Repeated challenges with nymphs or larvae lead to a reduction in duration of nymphal tick attachment and weight of recovered ticks consistent with the development of tick immunity. Only one of 18 I. scapularis-immune guinea pigs challenged with B. burgdorferi-infected nymphal ticks became infected, whereas 10 of 18 naive guinea pigs similarly challenged became infected. We conclude that tick immunity interferes with borrelial transmission.


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